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The kin17 Protein in Murine Melanoma Cells.
Ramos, Anelise C; Gaspar, Vanessa P; Kelmer, Sabrina M G; Sellani, Tarciso A; Batista, Ana G U; De Lima Neto, Quirino A; Rodrigues, Elaine G; Fernandez, Maria A.
Affiliation
  • Ramos AC; Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, 87020-900 Maringá, Paraná, Brazil. anelise.andre@gmail.com.
  • Gaspar VP; Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, 87020-900 Maringá, Paraná, Brazil. vapigas@gmail.com.
  • Kelmer SM; Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, 87020-900 Maringá, Paraná, Brazil. sabrinamg12@hotmail.com.
  • Sellani TA; Laboratório de Imunobiologia do Câncer, Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, 04023-062 São Paulo, São Paulo, Brazil. tarcis.sellani@gmail.com.
  • Batista AG; Laboratório de Imunobiologia do Câncer, Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, 04023-062 São Paulo, São Paulo, Brazil. anagurbanin@gmail.com.
  • De Lima Neto QA; Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, 87020-900 Maringá, Paraná, Brazil. qalneto@gmail.com.
  • Rodrigues EG; Laboratório de Imunobiologia do Câncer, Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, 04023-062 São Paulo, São Paulo, Brazil. rodrigues.elaine@unifesp.br.
  • Fernandez MA; Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, 87020-900 Maringá, Paraná, Brazil. mafernandez@uem.br.
Int J Mol Sci ; 16(11): 27912-20, 2015 Nov 24.
Article in En | MEDLINE | ID: mdl-26610484
kin17 has been described as a protein involved in the processes of DNA replication initiation, DNA recombination, and DNA repair. kin17 has been studied as a potential molecular marker of breast cancer. This work reports the detection and localization of this protein in the murine melanoma cell line B16F10-Nex2 and in two derived subclones with different metastatic potential, B16-8HR and B16-10CR. Nuclear and chromatin-associated protein fractions were analyzed, and kin17 was detected in all fractions, with an elevated concentration observed in the chromatin-associated fraction of the clone with low metastatic potential, suggesting that the kin17 expression level could be a marker of melanoma.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / DNA-Binding Proteins / Melanoma Limits: Animals Language: En Journal: Int J Mol Sci Year: 2015 Document type: Article Affiliation country: Brazil Country of publication: Switzerland
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / DNA-Binding Proteins / Melanoma Limits: Animals Language: En Journal: Int J Mol Sci Year: 2015 Document type: Article Affiliation country: Brazil Country of publication: Switzerland