Differential utilization of nuclear and extranuclear receptor signaling pathways in the actions of estrogens, SERMs, and a tissue-selective estrogen complex (TSEC).

Madak-Erdogan, Zeynep; Gong, Ping; Katzenellenbogen, Benita S

Madak-Erdogan, Zeynep; Gong, Ping; Katzenellenbogen, Benita S.

Affiliation

Madak-Erdogan Z; Department of Molecular and Integrative Physiology, University of Illinois, Urbana, IL 61801, United States.
Gong P; Department of Molecular and Integrative Physiology, University of Illinois, Urbana, IL 61801, United States.
Katzenellenbogen BS; Department of Molecular and Integrative Physiology, University of Illinois, Urbana, IL 61801, United States. Electronic address: katzenel@illinois.edu.

J Steroid Biochem Mol Biol ; 158: 198-206, 2016 Apr.

Article in En | MEDLINE | ID: mdl-26689478

Subject(s)

Estradiol/pharmacology; Estrogen Receptor alpha/metabolism; Estrogens, Conjugated (USP)/pharmacology; Estrogens/pharmacology; Mitogen-Activated Protein Kinase 1/metabolism; Selective Estrogen Receptor Modulators/pharmacology; Binding Sites; Cell Proliferation/drug effects; Chromatin/metabolism; Gene Expression Profiling; Humans; MCF-7 Cells; Oligonucleotide Array Sequence Analysis; RNA, Messenger/genetics; Signal Transduction/drug effects

Key words

Bazedoxifene; Breast cancer; Estrogen receptor; MAP kinases; SERM; TSEC; Tissue-selective estrogen complexes

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Estrogens, Conjugated (USP) / Mitogen-Activated Protein Kinase 1 / Selective Estrogen Receptor Modulators / Estrogen Receptor alpha / Estradiol / Estrogens Limits: Humans Language: En Journal: J Steroid Biochem Mol Biol Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA Year: 2016 Document type: Article Affiliation country: United States Country of publication: United kingdom

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