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Vaginal Inflammation: Association between Leukocyte Concentration and Levels of Immune Mediators.
Beghini, Joziani; Giraldo, Paulo C; Eleutério, José; Amaral, Rose Luce do; Polpeta, Nádia C; Gonçalves, Ana Katherine.
Affiliation
  • Beghini J; Department of Gynecology and Obstetrics, University of Campinas, Campinas, Brazil.
  • Giraldo PC; Department of Gynecology and Obstetrics, University of Campinas, Campinas, Brazil.
  • Eleutério J; Department of Motherhood and Child, Federal University of Ceará, Fortaleza, Brazil.
  • Amaral RL; Department of Gynecology and Obstetrics, University of Campinas, Campinas, Brazil.
  • Polpeta NC; Department of Gynecology and Obstetrics, University of Campinas, Campinas, Brazil.
  • Gonçalves AK; Department of Gynecology and Obstetrics, Federal University of Rio Grande do Norte, Natal, Brazil.
Am J Reprod Immunol ; 75(2): 126-33, 2016 Feb.
Article in En | MEDLINE | ID: mdl-26773532
PROBLEM: A wide variety of mediators are involved in inflammatory processes. However, the identity of those participating in vaginal immune responses has not been established. We correlated extracellular matrix metalloproteinase inducer (EMMPRIN), matrix metalloproteinase-8 (MMP-8), hyaluronan (HA), hyaluronidase-1 (Hyal-1), human ß-defensin-2 (hBD2), and neutrophil gelatinase-associated lipocalin (NGAL) concentrations with the extent of leukocyte infiltration into the vagina and suggest their participation in vaginal inflammation. METHODS OF STUDY: Vaginal fluid was obtained from 233 women seen at the outpatient clinic in the Department of Obstetrics and Gynecology at Campinas University, Brazil. The magnitude of vaginal inflammation was determined by the leukocyte count on vaginal smears and categorized as no inflammation (0 leukocytes/field), moderate inflammation (1-4 leukocytes/field), and intense inflammation (>4 leukocytes/field). Concentrations of EMMPRIN, MMP-8, HA, Hyal-1, hBD2, and NGAL were determined in vaginal fluid by ELISA. RESULTS: EMMPRIN, MMP-8, HA, hBD2, and NGAL concentration increased with elevated leukocyte numbers (P < 0.05), while Hyal-1 did not. EMMPRIN concentrations were correlated with HA and MMP-8 levels. CONCLUSION: EMMPRIN, MMP-8, HA, ß-defensin, and NGAL are elevated in women with vaginal inflammation.
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vaginitis / Acute-Phase Proteins / Proto-Oncogene Proteins / Matrix Metalloproteinase 8 / Beta-Defensins / Basigin / Lipocalins / Hyaluronic Acid Type of study: Risk_factors_studies Limits: Adult / Female / Humans Language: En Journal: Am J Reprod Immunol Year: 2016 Document type: Article Affiliation country: Brazil Country of publication: Denmark

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vaginitis / Acute-Phase Proteins / Proto-Oncogene Proteins / Matrix Metalloproteinase 8 / Beta-Defensins / Basigin / Lipocalins / Hyaluronic Acid Type of study: Risk_factors_studies Limits: Adult / Female / Humans Language: En Journal: Am J Reprod Immunol Year: 2016 Document type: Article Affiliation country: Brazil Country of publication: Denmark