Upregulation of the sodium channel NaVß4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local dorsal root ganglion inflammation.

Xie, Wenrui; Tan, Zhi-Yong; Barbosa, Cindy; Strong, Judith A; Cummins, Theodore R; Zhang, Jun-Ming

Xie, Wenrui; Tan, Zhi-Yong; Barbosa, Cindy; Strong, Judith A; Cummins, Theodore R; Zhang, Jun-Ming.

Affiliation

Xie W; Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA Department of Pharmacology and Toxicology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.

Pain ; 157(4): 879-891, 2016 Apr.

Article in En | MEDLINE | ID: mdl-26785322

Subject(s)

Action Potentials/drug effects; Behavior, Animal/physiology; Pain/metabolism; Sensory Receptor Cells/drug effects; Sodium Channels/metabolism; Voltage-Gated Sodium Channel beta-4 Subunit/metabolism; Action Potentials/physiology; Animals; Female; Ganglia, Spinal/metabolism; Inflammation/metabolism; Male; Membrane Potentials/drug effects; Rats, Sprague-Dawley; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / Sensory Receptor Cells / Behavior, Animal / Action Potentials / Sodium Channels / Voltage-Gated Sodium Channel beta-4 Subunit Limits: Animals Language: En Journal: Pain Year: 2016 Document type: Article Affiliation country: United States Country of publication: United States

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