Isotope Labeling of Biomolecules: Structural Analysis of Viruses by HDX-MS.

Guttman, Miklos; Lee, Kelly K

Guttman, Miklos; Lee, Kelly K.

Affiliation

Guttman M; Department of Medicinal Chemistry, University of Washington, Seattle, Washington, USA. Electronic address: mguttman@u.washington.edu.
Lee KK; Department of Medicinal Chemistry, University of Washington, Seattle, Washington, USA. Electronic address: klee@u.washington.edu.

Methods Enzymol ; 566: 405-26, 2016.

Article in En | MEDLINE | ID: mdl-26791988

Subject(s)

Deuterium Exchange Measurement/methods; Isotope Labeling/methods; Viral Proteins/chemistry; Viruses/chemistry; Amino Acid Sequence/genetics; Mass Spectrometry; Protein Conformation; Viral Proteins/isolation & purification; Viruses/isolation & purification

Key words

Amide exchange; Capsid; Conformational dynamics; Glycoprotein; HDX-MS; Hydrogen deuterium exchange; Local flexibility; Protection factor; Protein structure; Structural mass spectrometry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Proteins / Viruses / Deuterium Exchange Measurement / Isotope Labeling Language: En Journal: Methods Enzymol Year: 2016 Document type: Article Country of publication: United States

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