Ceramide Induces Human Hepcidin Gene Transcription through JAK/STAT3 Pathway.

Lu, Sizhao; Natarajan, Sathish Kumar; Mott, Justin L; Kharbanda, Kusum K; Harrison-Findik, Duygu Dee

Lu, Sizhao; Natarajan, Sathish Kumar; Mott, Justin L; Kharbanda, Kusum K; Harrison-Findik, Duygu Dee.

Affiliation

Lu S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE, 68198-5870, United States of America.
Natarajan SK; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE, 68198-5870, United States of America.
Mott JL; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE, 68198-5870, United States of America.
Kharbanda KK; Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, 982000 Nebraska Medical Center, Omaha, NE, 68198-2000, United States of America.
Harrison-Findik DD; Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, 982000 Nebraska Medical Center, Omaha, NE, 68198-2000, United States of America.

PLoS One ; 11(1): e0147474, 2016.

Article in En | MEDLINE | ID: mdl-26807955

Subject(s)

Ceramides/pharmacology; Hepcidins/biosynthesis; Janus Kinases/physiology; STAT3 Transcription Factor/physiology; Signal Transduction/drug effects; Transcription, Genetic/drug effects; Anthracenes/pharmacology; Chromatin Immunoprecipitation; Dactinomycin/pharmacology; Hep G2 Cells; Hepcidins/genetics; Humans; Iron/metabolism; Liver/metabolism; Mutagenesis, Site-Directed; NF-kappa B/metabolism; Non-alcoholic Fatty Liver Disease/epidemiology; Non-alcoholic Fatty Liver Disease/etiology; Non-alcoholic Fatty Liver Disease/metabolism; Obesity/complications; Obesity/metabolism; Phosphorylation/drug effects; Prevalence; Promoter Regions, Genetic/drug effects; Promoter Regions, Genetic/genetics; Protein Kinase Inhibitors/pharmacology; Protein Processing, Post-Translational/drug effects; RNA Interference; RNA, Messenger/biosynthesis; RNA, Messenger/genetics; RNA, Small Interfering/genetics; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Response Elements; STAT3 Transcription Factor/antagonists & inhibitors; STAT3 Transcription Factor/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription, Genetic / Signal Transduction / Ceramides / STAT3 Transcription Factor / Janus Kinases / Hepcidins Type of study: Etiology_studies / Prevalence_studies / Risk_factors_studies Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2016 Document type: Article Affiliation country: United States Country of publication: United States

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