Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation.

Zhou, Linjiao; Holt, Matthew T; Ohashi, Nami; Zhao, Aishan; Müller, Manuel M; Wang, Boyuan; Muir, Tom W

Zhou, Linjiao; Holt, Matthew T; Ohashi, Nami; Zhao, Aishan; Müller, Manuel M; Wang, Boyuan; Muir, Tom W.

Affiliation

Zhou L; Department of Chemistry, Princeton University, Princeton, 08544 New Jersey, USA.
Holt MT; Laboratory of Synthetic Protein Chemistry, The Rockefeller University, New York, 10065 New York, USA.
Ohashi N; Department of Chemistry, Princeton University, Princeton, 08544 New Jersey, USA.
Zhao A; Department of Chemistry, Princeton University, Princeton, 08544 New Jersey, USA.
Müller MM; Department of Chemistry, Princeton University, Princeton, 08544 New Jersey, USA.
Wang B; Department of Chemistry, Princeton University, Princeton, 08544 New Jersey, USA.
Muir TW; Laboratory of Synthetic Protein Chemistry, The Rockefeller University, New York, 10065 New York, USA.

Nat Commun ; 7: 10589, 2016 Feb 02.

Article in En | MEDLINE | ID: mdl-26830124

Subject(s)

Gene Expression Regulation, Enzymologic/physiology; Histones/metabolism; Methyltransferases/metabolism; Nucleosomes; Histone-Lysine N-Methyltransferase; Histones/genetics; Humans; Methylation; Methyltransferases/genetics; Models, Molecular; Protein Binding; Protein Conformation; Ubiquitinated Proteins

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histones / Nucleosomes / Gene Expression Regulation, Enzymologic / Methyltransferases Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2016 Document type: Article Affiliation country: United States Country of publication: United kingdom

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