Ursolic acid prevents augmented peripheral inflammation and inflammatory hyperalgesia in high-fat diet-induced obese rats by restoring downregulated spinal PPAR&#945;.

Zhang, Yanan; Song, Chengwei; Li, Haiou; Hou, Jingdong; Li, Dongliang

Ursolic acid prevents augmented peripheral inflammation and inflammatory hyperalgesia in high-fat diet-induced obese rats by restoring downregulated spinal PPARα.

Zhang, Yanan; Song, Chengwei; Li, Haiou; Hou, Jingdong; Li, Dongliang.

Affiliation

Zhang Y; Department of Anesthesiology, Jining First People's Hospital, Jining, Shandong 272011, P.R. China.
Song C; Department of Anesthesiology, Jining First People's Hospital, Jining, Shandong 272011, P.R. China.
Li H; Department of Anesthesiology, Jining First People's Hospital, Jining, Shandong 272011, P.R. China.
Hou J; Department of Anesthesiology, Jining First People's Hospital, Jining, Shandong 272011, P.R. China.
Li D; Department of Anesthesiology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China.

Mol Med Rep ; 13(6): 5309-16, 2016 Jun.

Article in En | MEDLINE | ID: mdl-27108888

Subject(s)

Dietary Fats/adverse effects; Down-Regulation/drug effects; Hyperalgesia/drug therapy; Obesity/drug therapy; PPAR alpha/biosynthesis; Spine/metabolism; Triterpenes/pharmacology; Animals; Dietary Fats/pharmacology; Hyperalgesia/chemically induced; Hyperalgesia/metabolism; Hyperalgesia/pathology; Male; Obesity/chemically induced; Obesity/metabolism; Obesity/pathology; Rats; Rats, Sprague-Dawley; Spine/pathology; Ursolic Acid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spine / Triterpenes / Dietary Fats / Down-Regulation / PPAR alpha / Hyperalgesia / Obesity Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Mol Med Rep Year: 2016 Document type: Article Country of publication: Greece

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