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Cephalosporins inhibit human metallo ß-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.
Lee, Sook Y; Brem, Jürgen; Pettinati, Ilaria; Claridge, Timothy D W; Gileadi, Opher; Schofield, Christopher J; McHugh, Peter J.
Affiliation
  • Lee SY; Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK. peter.mchugh@imm.ox.ac.uk and Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK. christopher.schofield@chem.ox.ac.uk.
  • Brem J; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK. christopher.schofield@chem.ox.ac.uk.
  • Pettinati I; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK. christopher.schofield@chem.ox.ac.uk.
  • Claridge TD; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK. christopher.schofield@chem.ox.ac.uk.
  • Gileadi O; Structural Genomics Consortium, Old Road Campus Research Building, Roosevelt Drive, University of Oxford, OX3 7DQ, UK.
  • Schofield CJ; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK. christopher.schofield@chem.ox.ac.uk.
  • McHugh PJ; Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK. peter.mchugh@imm.ox.ac.uk.
Chem Commun (Camb) ; 52(40): 6727-30, 2016 05 10.
Article in En | MEDLINE | ID: mdl-27121860

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Beta-Lactamases / Nuclear Proteins / Cephalosporins / DNA Repair Enzymes / DNA Repair / Enzyme Inhibitors / Exodeoxyribonucleases Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2016 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Beta-Lactamases / Nuclear Proteins / Cephalosporins / DNA Repair Enzymes / DNA Repair / Enzyme Inhibitors / Exodeoxyribonucleases Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2016 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom