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Are Obese Individuals with no Feature of Metabolic Syndrome but Increased Waist Circumference Really Healthy? A Cross Sectional Study.
Chiheb, S; Cosson, E; Banu, I; Hamo-Tchatchouang, E; Cussac-Pillegand, C; Nguyen, M T; Valensi, P.
Affiliation
  • Chiheb S; Department of Endocrinology-Diabetology-Nutrition, AP-HP, Jean Verdier Hospital, Paris Nord University, CRNH-IdF, CINFO, Bondy, France.
  • Cosson E; Department of Endocrinology-Diabetology-Nutrition, AP-HP, Jean Verdier Hospital, Paris Nord University, CRNH-IdF, CINFO, Bondy, France.
  • Banu I; Department of Endocrinology-Diabetology-Nutrition, AP-HP, Jean Verdier Hospital, Paris Nord University, CRNH-IdF, CINFO, Bondy, France.
  • Hamo-Tchatchouang E; Department of Endocrinology-Diabetology-Nutrition, AP-HP, Jean Verdier Hospital, Paris Nord University, CRNH-IdF, CINFO, Bondy, France.
  • Cussac-Pillegand C; Department of Endocrinology-Diabetology-Nutrition, AP-HP, Jean Verdier Hospital, Paris Nord University, CRNH-IdF, CINFO, Bondy, France.
  • Nguyen MT; Department of Endocrinology-Diabetology-Nutrition, AP-HP, Jean Verdier Hospital, Paris Nord University, CRNH-IdF, CINFO, Bondy, France.
  • Valensi P; Department of Endocrinology-Diabetology-Nutrition, AP-HP, Jean Verdier Hospital, Paris Nord University, CRNH-IdF, CINFO, Bondy, France.
Exp Clin Endocrinol Diabetes ; 124(7): 410-6, 2016 Jul.
Article in En | MEDLINE | ID: mdl-27219879
AIM: Patients displaying the metabolically healthy but obese phenotype have an intermediate cardiometabolic prognosis compared to normal weight healthy and metabolically unhealthy obese subjects. We aimed to evaluate the proportion of patients with a definite metabolically healthy obese phenotype and better characterize them. METHODS: Definite metabolically healthy obese phenotype was defined as having none of the International Diabetes Federation metabolic syndrome criteria, excluding waist circumference. We recruited 1 159 obese patients (body mass index 38.4±6.3 kg/m(2)) including 943 women, without known diabetes. Patients were characterized for cardiometabolic disorders. RESULTS: As the 202 (17.4%) metabolically healthy obese individuals were younger and had lower body mass indexes than the 957 metabolically unhealthy obese patients, they were matched for gender, age and body mass index with 404 metabolically unhealthy obese patients. In addition to the features of metabolic syndrome, when compared to unhealthy subjects, definite metabolically healthy obese patients were less frequently found with either homeostasis model assessment of insulin resistance index>3 (23.6 vs. 38.9%, p<0.001), or abnormal oral glucose tolerance test (13.9 vs. 33.9%, p<0.001), or HbA1c value≥5.7% (43.9 vs. 54.2%, p<0.05) or pulse pressure≥60 mmHg (11.7 vs. 64.9%, p<0.001). However, there were no significant differences in the prevalence of microalbuminuria (11.1 vs. 12.3%), cardiac autonomic dysfunction (45.5 vs. 35.3%) and fatty liver index ≥ 60 (5.6 vs. 10.2%). CONCLUSION: Our data do not support the characterization of metabolically healthy obesity, even definite, as really healthy, as many patients with this phenotype have abnormal cardiovascular markers and glucose or liver abnormalities. HbA1c measurement seems to be more sensitive than OGTT to detect dysglycemia in this population.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Metabolic Syndrome / Waist Circumference / Obesity Type of study: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Exp Clin Endocrinol Diabetes Journal subject: ENDOCRINOLOGIA Year: 2016 Document type: Article Affiliation country: France Country of publication: Germany

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Metabolic Syndrome / Waist Circumference / Obesity Type of study: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Exp Clin Endocrinol Diabetes Journal subject: ENDOCRINOLOGIA Year: 2016 Document type: Article Affiliation country: France Country of publication: Germany