Rapamycin results in Bim-mediated loss of thymic regulatory T cells during development in organ culture.

Overall, Sarah A; van Driel, Ian R; Gleeson, Paul A

Overall, Sarah A; van Driel, Ian R; Gleeson, Paul A.

Affiliation

Overall SA; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.
van Driel IR; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.
Gleeson PA; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia pgleeson@unimelb.edu.au.

Int Immunol ; 28(10): 513-518, 2016 10.

Article in En | MEDLINE | ID: mdl-27371614

Subject(s)

Bcl-2-Like Protein 11/metabolism; Sirolimus/pharmacology; T-Lymphocytes, Regulatory/drug effects; T-Lymphocytes, Regulatory/immunology; Thymus Gland/drug effects; Thymus Gland/immunology; Animals; Bcl-2-Like Protein 11/deficiency; Mice; Mice, Inbred BALB C; Mice, Knockout; Organ Culture Techniques; Thymus Gland/cytology

Key words

Bim; Foxp3+ regulatory T cells; mTORC1; rapamycin; thymus

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Collection: 01-internacional Database: MEDLINE Main subject: Thymus Gland / T-Lymphocytes, Regulatory / Sirolimus / Bcl-2-Like Protein 11 Limits: Animals Language: En Journal: Int Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2016 Document type: Article Affiliation country: Australia Country of publication: United kingdom

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