Synthesis and Assays of Inhibitors of Methyltransferases.

Cai, X-C; Kapilashrami, K; Luo, M

Cai, X-C; Kapilashrami, K; Luo, M.

Affiliation

Cai XC; Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Kapilashrami K; Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Luo M; Memorial Sloan Kettering Cancer Center, New York, NY, United States. Electronic address: luom@mskcc.org.

Methods Enzymol ; 574: 245-308, 2016.

Article in En | MEDLINE | ID: mdl-27423865

Subject(s)

Drug Design; Drug Evaluation, Preclinical/methods; Enzyme Assays/methods; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Methyltransferases/antagonists & inhibitors; Animals; Chemistry Techniques, Synthetic/methods; Enzyme Inhibitors/chemical synthesis; Humans; Methyltransferases/metabolism

Key words

Epigenetics; Inhibition; Methylation; S-Adenosyl-l-homocysteine; S-Adenosyl-l-methionine; Sinefungin; Structure-based inhibitor design

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Drug Evaluation, Preclinical / Enzyme Inhibitors / Enzyme Assays / Methyltransferases Limits: Animals / Humans Language: En Journal: Methods Enzymol Year: 2016 Document type: Article Affiliation country: United States

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