Genetics of Bariatric Surgery Outcomes.

Noel, Olivier F; Still, Christopher D; Gerhard, Glenn S

Noel, Olivier F; Still, Christopher D; Gerhard, Glenn S.

Affiliation

Noel OF; Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, Philadelphia, PA 19140, USA; Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA; DNAsimple, Philadelphia, PA, USA.
Still CD; Department of Gastroenterology and Nutrition, Geisinger Clinic, 100 North Academy Avenue, Danville, PA 17822, USA.
Gerhard GS; Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine, Temple University, 960 Medical Education and Research Building (MERB), 3500 North Broad Street, Philadelphia, PA 19140, USA. Electronic address: gsgerhard@Temple.edu.

Endocrinol Metab Clin North Am ; 45(3): 623-32, 2016 09.

Article in En | MEDLINE | ID: mdl-27519134

ABSTRACT

Outcomes after bariatric surgery can vary widely and seem to have a significant genetic component. Only a small number of candidate gene and genome-wide association studies have analyzed bariatric surgery outcomes. The role of bile acids in mediating the beneficial effects of bariatric surgery implicate genes regulated by the farnesoid X receptor transcription factor.

Subject(s)

Bariatric Surgery; Weight Loss/genetics; Bile Acids and Salts; Genome-Wide Association Study; Humans; Receptors, Cytoplasmic and Nuclear/genetics; Treatment Outcome

Key words

Bariatric surgery; Genetics; NAFLD; Type 2 diabetes mellitus; Weight loss

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Weight Loss / Bariatric Surgery Limits: Humans Language: En Journal: Endocrinol Metab Clin North Am Journal subject: ENDOCRINOLOGIA / METABOLISMO Year: 2016 Document type: Article Affiliation country: United States Country of publication: United States

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