Stabilization of Paclitaxel-Conjugated Micelles by Cross-Linking with Cystamine Compromises the Antitumor Effects against Two- and Three-Dimensional Tumor Cellular Models.

Du, Alice Wei; Lu, Hongxu; Stenzel, Martina

Du, Alice Wei; Lu, Hongxu; Stenzel, Martina.

Affiliation

Du AW; Centre for Advanced Macromolecular Design (CAMD), School of Chemical Engineering, and School of Chemistry, University of New South Wales , Sydney, NSW 2052, Australia.
Lu H; Centre for Advanced Macromolecular Design (CAMD), School of Chemical Engineering, and School of Chemistry, University of New South Wales , Sydney, NSW 2052, Australia.
Stenzel M; Centre for Advanced Macromolecular Design (CAMD), School of Chemical Engineering, and School of Chemistry, University of New South Wales , Sydney, NSW 2052, Australia.

Mol Pharm ; 13(11): 3648-3656, 2016 11 07.

Article in En | MEDLINE | ID: mdl-27654333

Subject(s)

Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Cystamine/chemistry; Cystamine/pharmacology; Micelles; Paclitaxel/chemistry; Paclitaxel/pharmacology; Cell Line, Tumor; Cell Survival/drug effects; Drug Carriers/chemistry; Humans; Male; Models, Theoretical; Polymers/chemistry; Prostatic Neoplasms/metabolism

Key words

cross-linking; cystamine; micelles; multicellular tumor spheroids; paclitaxel

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Collection: 01-internacional Database: MEDLINE Main subject: Paclitaxel / Cystamine / Micelles / Antineoplastic Agents Limits: Humans / Male Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2016 Document type: Article Affiliation country: Australia Country of publication: United States

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