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Invasive pulmonary fungal infections in patients with connective tissue disease: a retrospective study from northern China.
Ge, H F; Liu, X Q; Zhu, Y Q; Chen, H Q; Chen, G Z.
Affiliation
  • Ge HF; Department of Dermatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
  • Liu XQ; Department of Dermatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
  • Zhu YQ; Laboratory Department, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
  • Chen HQ; Department of Dermatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
  • Chen GZ; Department of Dermatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
Braz J Med Biol Res ; 49(10): e5531, 2016 Sep 22.
Article in En | MEDLINE | ID: mdl-27683823
Invasive pulmonary fungal infection (IPFI) is a potentially fatal complication in patients with connective tissue disease (CTD). The current study aimed to uncover the clinical characteristics and risk factors of patients with IPFI-CTD. The files of 2186 CTD patients admitted to a single center in northern China between January 2011 and December 2013 were retrospectively reviewed. A total of 47 CTD patients with IPFI were enrolled into this study and assigned to the CTD-IPFI group, while 47 uninfected CTD patients were assigned to the control group. Clinical manifestations were recorded, and risk factors of IPFI were calculated by stepwise logistical regression analysis. Forty-seven (2.15%) CTD patients developed IPFI. Systemic lupus erythematosus patients were responsible for the highest proportion (36.17%) of cases with IPFI. Candida albicans (72.3%) accounted for the most common fungal species. CTD-IPFI patients had significantly elevated white blood cell count, erythrocyte sedimentation rate, C-reactive protein and fasting glucose values compared to controls (P<0.05). Cough, sputum and blood in phlegm were the most common symptoms. Risk factors of IPFI in CTD included maximum prednisone dose ≥30 mg/day within 3 months prior to infection, anti-microbial drug therapy, and interstitial pneumonia. CTD patients who have underlying interstitial pneumonia, prior prednisone or multiple antibiotics, were more likely to develop IPFI.

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Observational_studies / Risk_factors_studies Language: En Journal: Braz J Med Biol Res Year: 2016 Document type: Article Affiliation country: China Country of publication: Brazil

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Observational_studies / Risk_factors_studies Language: En Journal: Braz J Med Biol Res Year: 2016 Document type: Article Affiliation country: China Country of publication: Brazil