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Blocking the flow of propionate into TCA cycle through a mutB knockout leads to a significant increase of erythromycin production by an industrial strain of Saccharopolyspora erythraea.
Chen, Chongchong; Hong, Ming; Chu, Ju; Huang, Mingzhi; Ouyang, Liming; Tian, Xiwei; Zhuang, Yingping.
Affiliation
  • Chen C; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, P.O.box 329, Shanghai, 200237, People's Republic of China.
  • Hong M; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, P.O.box 329, Shanghai, 200237, People's Republic of China.
  • Chu J; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, P.O.box 329, Shanghai, 200237, People's Republic of China. juchu@ecust.edu.cn.
  • Huang M; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, P.O.box 329, Shanghai, 200237, People's Republic of China. huangmz@ecust.edu.cn.
  • Ouyang L; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, P.O.box 329, Shanghai, 200237, People's Republic of China.
  • Tian X; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, P.O.box 329, Shanghai, 200237, People's Republic of China.
  • Zhuang Y; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, P.O.box 329, Shanghai, 200237, People's Republic of China.
Bioprocess Biosyst Eng ; 40(2): 201-209, 2017 Feb.
Article in En | MEDLINE | ID: mdl-27709326
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Propionates / Bacterial Proteins / Erythromycin / Citric Acid Cycle / Saccharopolyspora / Gene Knockdown Techniques / Methylmalonyl-CoA Mutase Language: En Journal: Bioprocess Biosyst Eng Journal subject: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Year: 2017 Document type: Article Country of publication: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Propionates / Bacterial Proteins / Erythromycin / Citric Acid Cycle / Saccharopolyspora / Gene Knockdown Techniques / Methylmalonyl-CoA Mutase Language: En Journal: Bioprocess Biosyst Eng Journal subject: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Year: 2017 Document type: Article Country of publication: Germany