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Circumventing furin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models.
Siner, Joshua I; Samelson-Jones, Benjamin J; Crudele, Julie M; French, Robert A; Lee, Benjamin J; Zhou, Shanzhen; Merricks, Elizabeth; Raymer, Robin; Nichols, Timothy C; Camire, Rodney M; Arruda, Valder R.
Affiliation
  • Siner JI; The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Samelson-Jones BJ; The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Crudele JM; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • French RA; The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Lee BJ; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Zhou S; The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Merricks E; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Raymer R; The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Nichols TC; The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Camire RM; University of North Carolina, Chapel Hill, North Carolina, USA.
  • Arruda VR; University of North Carolina, Chapel Hill, North Carolina, USA.
JCI Insight ; 1(16): e89371, 2016 Oct 06.
Article in En | MEDLINE | ID: mdl-27734034
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Factor VIII / Genetic Therapy / Furin / Hemophilia A Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: JCI Insight Year: 2016 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Factor VIII / Genetic Therapy / Furin / Hemophilia A Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: JCI Insight Year: 2016 Document type: Article Affiliation country: United States Country of publication: United States