MiR-335 regulates the chemo-radioresistance of small cell lung cancer cells by targeting PARP-1.

Luo, Yingshan; Tong, Lihua; Meng, Hui; Zhu, Weiliang; Guo, Linlang; Wei, Ting; Zhang, Jian

Luo, Yingshan; Tong, Lihua; Meng, Hui; Zhu, Weiliang; Guo, Linlang; Wei, Ting; Zhang, Jian.

Affiliation

Luo Y; Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Tong L; Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Meng H; Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Zhu W; Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Guo L; Department of Pathology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Wei T; Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address: 258077534@qq.com.
Zhang J; Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address: blacktiger@139.com.

Gene ; 600: 9-15, 2017 Feb 05.

Article in En | MEDLINE | ID: mdl-27871924

Subject(s)

Drug Resistance, Neoplasm/genetics; Lung Neoplasms/genetics; Lung Neoplasms/therapy; MicroRNAs/genetics; Poly (ADP-Ribose) Polymerase-1/antagonists & inhibitors; Poly (ADP-Ribose) Polymerase-1/genetics; Radiation Tolerance/genetics; Small Cell Lung Carcinoma/genetics; Small Cell Lung Carcinoma/therapy; Animals; Cell Line, Tumor; Cell Movement/genetics; Down-Regulation; Drug Resistance, Multiple/genetics; Humans; Lung Neoplasms/metabolism; Male; Mice; Mice, Nude; MicroRNAs/metabolism; Molecular Targeted Therapy; NF-kappa B/metabolism; Poly (ADP-Ribose) Polymerase-1/metabolism; Small Cell Lung Carcinoma/metabolism; Xenograft Model Antitumor Assays

Key words

Multi-drug resistance; NF-κB; PARP-1; Radioresistance; SCLC; miR-335

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radiation Tolerance / Drug Resistance, Neoplasm / MicroRNAs / Small Cell Lung Carcinoma / Poly (ADP-Ribose) Polymerase-1 / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Gene Year: 2017 Document type: Article Affiliation country: China Country of publication: Netherlands

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google