Imaging mass spectrometry in drug development and toxicology.

Karlsson, Oskar; Hanrieder, Jörg

Karlsson, Oskar; Hanrieder, Jörg.

Affiliation

Karlsson O; Center for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institute, 171 76, Stockholm, Sweden. oskar.karlsson@ki.se.
Hanrieder J; Department of Pharmaceutical Biosciences, Drug Safety and Toxicology, Uppsala University, 751 24, Uppsala, Sweden. oskar.karlsson@ki.se.

Arch Toxicol ; 91(6): 2283-2294, 2017 Jun.

Article in En | MEDLINE | ID: mdl-27933369

Subject(s)

Drug Discovery/instrumentation; Drugs, Investigational; Hazardous Substances; Molecular Imaging/methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods; Toxicology/instrumentation; Animals; Biomarkers/analysis; Drug Discovery/methods; Drugs, Investigational/pharmacokinetics; Drugs, Investigational/toxicity; Hazardous Substances/pharmacokinetics; Hazardous Substances/toxicity; Humans; Image Processing, Computer-Assisted; Spectrometry, Mass, Secondary Ion/methods; Tissue Distribution; Toxicology/methods

Key words

6-OHDA; BMAA; Biologics; L-DOPA; MALDI IMS; Neurotoxicology; Preclinical; SIMS; Small-molecule drugs; Toxins

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Toxicology / Hazardous Substances / Drugs, Investigational / Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Drug Discovery / Molecular Imaging Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Journal: Arch Toxicol Year: 2017 Document type: Article Affiliation country: Sweden Country of publication: Germany

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