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Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles.
Gregson, John M; Freitag, Daniel F; Surendran, Praveen; Stitziel, Nathan O; Chowdhury, Rajiv; Burgess, Stephen; Kaptoge, Stephen; Gao, Pei; Staley, James R; Willeit, Peter; Nielsen, Sune F; Caslake, Muriel; Trompet, Stella; Polfus, Linda M; Kuulasmaa, Kari; Kontto, Jukka; Perola, Markus; Blankenberg, Stefan; Veronesi, Giovanni; Gianfagna, Francesco; Männistö, Satu; Kimura, Akinori; Lin, Honghuang; Reilly, Dermot F; Gorski, Mathias; Mijatovic, Vladan; Munroe, Patricia B; Ehret, Georg B; Thompson, Alex; Uria-Nickelsen, Maria; Malarstig, Anders; Dehghan, Abbas; Vogt, Thomas F; Sasaoka, Taishi; Takeuchi, Fumihiko; Kato, Norihiro; Yamada, Yoshiji; Kee, Frank; Müller-Nurasyid, Martina; Ferrières, Jean; Arveiler, Dominique; Amouyel, Philippe; Salomaa, Veikko; Boerwinkle, Eric; Thompson, Simon G; Ford, Ian; Wouter Jukema, J; Sattar, Naveed; Packard, Chris J; Shafi Majumder, Abdulla Al.
Affiliation
  • Gregson JM; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK.
  • Freitag DF; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK.
  • Surendran P; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK.
  • Stitziel NO; 2 Departments of Medicine and Genetics, Washington University School of Medicine, St Louis, USA.
  • Chowdhury R; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK.
  • Burgess S; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK.
  • Kaptoge S; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK.
  • Gao P; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK.
  • Staley JR; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK.
  • Willeit P; 3 Department of Public Health and Primary Care, University of Cambridge, UK.
  • Nielsen SF; 4 Department of Neurology, Innsbruck Medical University, Austria.
  • Caslake M; 5 Copenhagen University Hospital, University of Copenhagen, Denmark.
  • Trompet S; 6 University of Glasgow, UK.
  • Polfus LM; 7 Leiden University Medical Centre, Netherlands.
  • Kuulasmaa K; 8 University of Texas Health Science Center Houston, USA.
  • Kontto J; 9 THL-National Institute for Health and Welfare, Helsinki, Finland.
  • Perola M; 9 THL-National Institute for Health and Welfare, Helsinki, Finland.
  • Blankenberg S; 10 Institute of Molecular Medicine FIMM, University of Helsinki, Finland.
  • Veronesi G; 11 Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
  • Gianfagna F; 12 Department of General and Interventional Cardiology, University Heart Centre Hamburg, Germany.
  • Männistö S; 13 University Medical Centre Hamburg Eppendorf, Hamburg, Germany.
  • Kimura A; 14 Research Centre, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy.
  • Lin H; 14 Research Centre, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy.
  • Reilly DF; 15 Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy.
  • Gorski M; 9 THL-National Institute for Health and Welfare, Helsinki, Finland.
  • Mijatovic V; 16 Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Japan.
  • Munroe PB; 18 The NHLBI's Framingham Heart Study, Framingham, USA.
  • Ehret GB; 19 Merck Research Laboratories, Genetics and Pharmacogenomics, Boston, USA.
  • Thompson A; 21 Department of Nephrology, University Hospital Regensburg, Germany.
  • Uria-Nickelsen M; 22 Department of Life and Reproduction Sciences, University of Verona, Italy.
  • Dehghan A; 23 Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK.
  • Vogt TF; 25 Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, USA.
  • Sasaoka T; 26 Cardiology, Department of Medicine, Geneva University Hospital, Switzerland.
  • Takeuchi F; 27 Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
  • Yamada Y; 28 UCB, Brussels, Belgium.
  • Kee F; 29 Clinical Research, Pfizer Worldwide R&D, Cambridge, USA.
  • Müller-Nurasyid M; 30 Clinical Research, Pfizer Worldwide R&D, Sollentuna, Sweden.
  • Ferrières J; 31 Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
  • Amouyel P; 32 Merck Research Laboratories, Cardiometabolic Disease, Kenilworth, USA.
  • Salomaa V; 33 CHDI Management/CHDI Foundation, Princeton, USA.
  • Boerwinkle E; 16 Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Japan.
  • Thompson SG; 34 Department of Gene Diagnostics and Therapeutics, Research Institute, National Centre for Global Health and Medicine, Tokyo, Japan.
  • Ford I; 34 Department of Gene Diagnostics and Therapeutics, Research Institute, National Centre for Global Health and Medicine, Tokyo, Japan.
  • Wouter Jukema J; 35 Department of Human Functional Genomics, Life Science Research Centre, Mie University, Japan.
  • Sattar N; 36 UKCRC Centre of Excellence for Public Health, Queens University, Belfast, Ireland.
  • Packard CJ; 37 Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany.
  • Shafi Majumder AA; 38 Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.
Eur J Prev Cardiol ; 24(5): 492-504, 2017 03.
Article in En | MEDLINE | ID: mdl-27940953
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oximes / Benzaldehydes / Coronary Disease / Molecular Targeted Therapy / Phospholipase A2 Inhibitors Type of study: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Eur J Prev Cardiol Year: 2017 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oximes / Benzaldehydes / Coronary Disease / Molecular Targeted Therapy / Phospholipase A2 Inhibitors Type of study: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Eur J Prev Cardiol Year: 2017 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom