Your browser doesn't support javascript.
loading
A clean photometric method for the determination of losartan potassium in pharmaceuticals exploiting light scattering effect and employing a multicommuted flow analysis approach.
Lima, Manoel J A; Reis, Boaventura F.
Affiliation
  • Lima MJA; Centro de energia Nuclear na Agricultura - Universidade de São Paulo, Avenida Centenário, 303, CEP 13416-000 Piracicaba, SP, Brazil.
  • Reis BF; Centro de energia Nuclear na Agricultura - Universidade de São Paulo, Avenida Centenário, 303, CEP 13416-000 Piracicaba, SP, Brazil. Electronic address: reis@cena.usp.br.
Talanta ; 164: 183-188, 2017 Mar 01.
Article in En | MEDLINE | ID: mdl-28107915
This paper describes an environmentally friendly procedure for the determination of losartan potassium (Los-K) in pharmaceuticals. The photometric method was based on the light scattering effect due to particles suspension, which were formed by the reaction of Los-K with Cu (II) ions. The method was automated employing a multicommuted flow analysis approach, implemented using solenoid mini-pumps for fluid propelling and a homemade LED based photometer. Under the optimized experimental conditions, the procedure showed a linear relationship in the concentration range of 23.2-417.6mgL-1 (r=0.9997, n=6), a relative standard deviation of 1.61% (n=10), a limit of detection (3.3*σ) estimated to be 12.1mgL-1, and a sampling rate of 140 determinations per hour. Each determination consumed 12µg of copper (II) acetate and generated 0.54mL of waste.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Photometry / Scattering, Radiation / Pharmaceutical Preparations / Losartan / Light Language: En Journal: Talanta Year: 2017 Document type: Article Affiliation country: Brazil Country of publication: Netherlands

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Photometry / Scattering, Radiation / Pharmaceutical Preparations / Losartan / Light Language: En Journal: Talanta Year: 2017 Document type: Article Affiliation country: Brazil Country of publication: Netherlands