Your browser doesn't support javascript.
loading
Acute norovirus gastroenteritis in children in a highly rotavirus-vaccinated population in Northeast Brazil.
Santos, Victor S; Gurgel, Ricardo Q; Cavalcante, Sandra M M; Kirby, Andrew; Café, Lilian P; Souto, Maria J; Dolabella, Silvio S; de Assis, Matheus R; Fumian, Tulio M; Miagostovich, Marize P; Cunliffe, Nigel A; Cuevas, Luis E.
Affiliation
  • Santos VS; Federal University of Sergipe, Aracaju, Brazil.
  • Gurgel RQ; Federal University of Sergipe, Aracaju, Brazil. Electronic address: ricardoqgurgel@gmail.com.
  • Cavalcante SM; Federal University of Sergipe, Aracaju, Brazil.
  • Kirby A; Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, UK.
  • Café LP; Federal University of Sergipe, Aracaju, Brazil.
  • Souto MJ; Federal University of Sergipe, Aracaju, Brazil.
  • Dolabella SS; Federal University of Sergipe, Aracaju, Brazil.
  • de Assis MR; Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Fumian TM; Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Miagostovich MP; Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Cunliffe NA; Department of Clinical Infection, Microbiology & Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.
  • Cuevas LE; Liverpool School of Tropical Medicine, Liverpool, UK.
J Clin Virol ; 88: 33-38, 2017 03.
Article in En | MEDLINE | ID: mdl-28160726
BACKGROUND: Gastroenteritis is one of the most important causes of morbidity and mortality in children and an important etiological agent is norovirus. OBJECTIVE: We describe the occurrence and characteristics of norovirus diarrhoea in children from Sergipe, Northeast-Brazil, over two consecutive periods of three years following rotavirus vaccine introduction. STUDY DESIGN: A cross sectional hospital-based survey conducted from October-2006 to September-2009 and from July-2011 to January-2013. Acute diarrhoea cases had a stool sample collected and tested for norovirus by RT-PCR and positive samples were sequenced. RESULTS: In total 280 (19.6%) of 1432 samples were norovirus positive, including 204 (18.3%) of 1113 samples collected during the first period and 76 (23.9%) of 318 collected during the second period. The proportion of children with norovirus infection increased significantly through the second study period (χ2 for trend=6.7; p=0.009), was more frequent in rotavirus vaccinated and in younger children (p<0.001). Of 280 norovirus-positive specimens, 188 (67.1%) were sequenced. Of these, 12 were genogroup I and 176 genogroup II. The main genotype was GII.4 (149/188, 79.3%), followed by GII.2 (6, 3.2%) and GII.6 (5, 2.6%). CONCLUSION: Norovirus annual detection rates increased over the study period. The detection of norovirus was higher among young children.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Caliciviridae Infections / Norovirus / Diarrhea / Gastroenteritis Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Child, preschool / Female / Humans / Infant / Male Country/Region as subject: America do sul / Brasil Language: En Journal: J Clin Virol Journal subject: VIROLOGIA Year: 2017 Document type: Article Affiliation country: Brazil Country of publication: Netherlands

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Caliciviridae Infections / Norovirus / Diarrhea / Gastroenteritis Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Child, preschool / Female / Humans / Infant / Male Country/Region as subject: America do sul / Brasil Language: En Journal: J Clin Virol Journal subject: VIROLOGIA Year: 2017 Document type: Article Affiliation country: Brazil Country of publication: Netherlands