Pseudohypoxia induced by miR-126 deactivation promotes migration and therapeutic resistance in renal cell carcinoma.

Liu, Weijun; Chen, Hanxiang; Wong, Nathan; Haynes, Wesley; Baker, Callie M; Wang, Xiaowei

Liu, Weijun; Chen, Hanxiang; Wong, Nathan; Haynes, Wesley; Baker, Callie M; Wang, Xiaowei.

Affiliation

Liu W; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Chen H; Institute of Pathogenic Biology, Shandong University School of Medicine, Jinan, Shandong, China; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Wong N; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Haynes W; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Baker CM; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Wang X; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: xiaowei.wang@wustl.edu.

Cancer Lett ; 394: 65-75, 2017 05 28.

Article in En | MEDLINE | ID: mdl-28257806

Subject(s)

Antineoplastic Agents/pharmacology; Carcinoma, Renal Cell/therapy; Cell Movement; Cisplatin/pharmacology; Drug Resistance, Neoplasm; Kidney Neoplasms/therapy; MicroRNAs/metabolism; Radiation Tolerance; Tumor Hypoxia; Basic Helix-Loop-Helix Transcription Factors/genetics; Basic Helix-Loop-Helix Transcription Factors/metabolism; CRISPR-Cas Systems; Carcinoma, Renal Cell/metabolism; Carcinoma, Renal Cell/pathology; Cell Movement/drug effects; Cell Movement/radiation effects; Computational Biology; Databases, Genetic; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HEK293 Cells; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Kidney Neoplasms/genetics; Kidney Neoplasms/metabolism; Kidney Neoplasms/pathology; Large Neutral Amino Acid-Transporter 1/genetics; Large Neutral Amino Acid-Transporter 1/metabolism; MicroRNAs/genetics; Neoplasm Invasiveness; Plasminogen Activator Inhibitor 1/genetics; Plasminogen Activator Inhibitor 1/metabolism; RNA Interference; Signal Transduction/drug effects; Signal Transduction/radiation effects; TOR Serine-Threonine Kinases/genetics; TOR Serine-Threonine Kinases/metabolism; Transfection; Von Hippel-Lindau Tumor Suppressor Protein/genetics; Von Hippel-Lindau Tumor Suppressor Protein/metabolism

Key words

Hypoxia; MicroRNA; Pseudohypoxia; Renal cell carcinoma; miR-126

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radiation Tolerance / Carcinoma, Renal Cell / Cell Movement / Cisplatin / Drug Resistance, Neoplasm / MicroRNAs / Tumor Hypoxia / Kidney Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Language: En Journal: Cancer Lett Year: 2017 Document type: Article Affiliation country: United States Country of publication: Ireland

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