Aberrant Th2 inflammation drives dysfunction of alveolar macrophages and susceptibility to bacterial pneumonia.

Moser, Emily K; Field, Natania S; Oliver, Paula M

Moser, Emily K; Field, Natania S; Oliver, Paula M.

Affiliation

Moser EK; Cell Pathology Division, Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA. Emily.k.moser@gmail.com.
Field NS; Cell and Molecular Biology Program, Perelman School of Medicine, University of Pennsylvania, 19104, Philadelphia, PA, USA.
Oliver PM; Cell Pathology Division, Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA.

Cell Mol Immunol ; 15(5): 480-492, 2018 May.

Article in En | MEDLINE | ID: mdl-28260794

Subject(s)

Disease Susceptibility; Inflammation/immunology; Macrophages, Alveolar/immunology; Pneumonia, Bacterial/immunology; Th2 Cells/immunology; Animals; Cell Count; Cytokines/metabolism; Inflammation/pathology; Lung/immunology; Lung/microbiology; Lung/pathology; Macrophages, Alveolar/pathology; Mice; Pneumonia, Bacterial/microbiology; Pneumonia, Bacterial/pathology; STAT6 Transcription Factor/deficiency; STAT6 Transcription Factor/metabolism; Signal Transduction; Ubiquitin-Protein Ligases/deficiency; Ubiquitin-Protein Ligases/metabolism

Key words

Itch; Th2 cell; alveolar macrophage; bacterial pneumonia

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Macrophages, Alveolar / Th2 Cells / Pneumonia, Bacterial / Disease Susceptibility / Inflammation Limits: Animals Language: En Journal: Cell Mol Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Document type: Article Affiliation country: United States Country of publication: China

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