Assessment of new triplet forming artificial nucleobases as RNA ligands directed towards HCV IRES IIId loop.

Safir Filho, Mauro; Martin, Anthony R; Benhida, Rachid

Safir Filho, Mauro; Martin, Anthony R; Benhida, Rachid.

Affiliation

Safir Filho M; Université Côte d'Azur, CNRS, Institut de Chimie de Nice UMR7272, 06108 Nice, France; CAPES Foundation, Ministry of Education of Brazil, Brasília DF 70040-020, Brazil.
Martin AR; Université Côte d'Azur, CNRS, Institut de Chimie de Nice UMR7272, 06108 Nice, France.
Benhida R; Université Côte d'Azur, CNRS, Institut de Chimie de Nice UMR7272, 06108 Nice, France. Electronic address: benhida@unice.fr.

Bioorg Med Chem Lett ; 27(8): 1780-1783, 2017 04 15.

Article in En | MEDLINE | ID: mdl-28274634

Subject(s)

5' Untranslated Regions/drug effects; Amino Acids/pharmacology; Antiviral Agents/pharmacology; Hepacivirus/drug effects; Purines/pharmacology; Pyrimidines/pharmacology; RNA, Viral/metabolism; Amino Acids/chemistry; Antiviral Agents/chemistry; Base Pairing/drug effects; Base Sequence; Hepacivirus/chemistry; Hepacivirus/metabolism; Hepatitis C/drug therapy; Hepatitis C/virology; Humans; Ligands; Nucleic Acid Conformation; Purines/chemistry; Pyrimidines/chemistry; RNA, Viral/chemistry

Key words

Binding assay; Hepatitis virus C; IRES IIId loop; Inhibitors; RNA ligands

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Purines / Pyrimidines / RNA, Viral / Hepacivirus / 5' Untranslated Regions / Amino Acids Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2017 Document type: Article Affiliation country: Brazil Country of publication: United kingdom

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