Bioenergetics-based modeling of Plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks.

Chiappino-Pepe, Anush; Tymoshenko, Stepan; Ataman, Meriç; Soldati-Favre, Dominique; Hatzimanikatis, Vassily

Chiappino-Pepe, Anush; Tymoshenko, Stepan; Ataman, Meriç; Soldati-Favre, Dominique; Hatzimanikatis, Vassily.

Affiliation

Chiappino-Pepe A; Laboratory of Computational Systems Biotechnology, École Polytechnique Fédérale de Lausanne, EPFL, Lausanne, Switzerland.
Tymoshenko S; Laboratory of Computational Systems Biotechnology, École Polytechnique Fédérale de Lausanne, EPFL, Lausanne, Switzerland.
Ataman M; Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, CMU, Geneva, Switzerland.
Soldati-Favre D; Laboratory of Computational Systems Biotechnology, École Polytechnique Fédérale de Lausanne, EPFL, Lausanne, Switzerland.
Hatzimanikatis V; Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, CMU, Geneva, Switzerland.

PLoS Comput Biol ; 13(3): e1005397, 2017 03.

Article in En | MEDLINE | ID: mdl-28333921

Subject(s)

Energy Metabolism/physiology; Genes, Essential/physiology; Models, Biological; Nutritional Requirements/physiology; Plasmodium falciparum/physiology; Protozoan Proteins/metabolism; Computer Simulation; Metabolic Flux Analysis/methods; Metabolome/physiology; Thermodynamics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Protozoan Proteins / Genes, Essential / Energy Metabolism / Models, Biological / Nutritional Requirements Type of study: Prognostic_studies Language: En Journal: PLoS Comput Biol Journal subject: BIOLOGIA / INFORMATICA MEDICA Year: 2017 Document type: Article Affiliation country: Switzerland Country of publication: United States

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