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Iron(II)-Catalyzed Hydrophosphination of Isocyanates.
Sharpe, Helen R; Geer, Ana M; Lewis, William; Blake, Alexander J; Kays, Deborah L.
Affiliation
  • Sharpe HR; School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
  • Geer AM; School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
  • Lewis W; School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
  • Blake AJ; School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
  • Kays DL; School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Angew Chem Int Ed Engl ; 56(17): 4845-4848, 2017 04 18.
Article in En | MEDLINE | ID: mdl-28338260
The first transition metal catalyzed hydrophosphination of isocyanates is presented. The use of low-coordinate iron(II) precatalysts leads to an unprecedented catalytic double insertion of isocyanates into the P-H bond of diphenylphosphine to yield phosphinodicarboxamides [Ph2 PC(=O)N(R)C(=O)N(H)R], a new family of derivatized organophosphorus compounds. This remarkable result can be attributed to the low-coordinate nature of the iron(II) centers whose inherent electron deficiency enables a Lewis-acid mechanism in which a combination of the steric pocket of the metal center and substrate size determines the reaction products and regioselectivity.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Angew Chem Int Ed Engl Year: 2017 Document type: Article Country of publication: Germany

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Angew Chem Int Ed Engl Year: 2017 Document type: Article Country of publication: Germany