Oxidative stress and lens opacity: an overall approach to screening anticataractous drugs.

Tissié, G; Guillermet, V; Latour, E; Coquelet, C; Bonne, C

Tissié, G; Guillermet, V; Latour, E; Coquelet, C; Bonne, C.

Affiliation

Tissié G; Centre de Recherche, Laboratoires Chauvin S.A., Montpellier, France.

Ophthalmic Res ; 20(1): 27-30, 1988.

Article in En | MEDLINE | ID: mdl-2837711

ABSTRACT

Since oxidative stress is a well substantiated hypothesis of cataract pathogenesis, screening was performed in acellular systems in order to select scavengers of reactive oxygen species; the selected compounds are at present being tested in lens culture and in animal models.

Subject(s)

Cataract/drug therapy; Lens, Crystalline/metabolism; Oxygen/metabolism; Animals; Anions/metabolism; Cataract/chemically induced; Drug Evaluation, Preclinical; Free Radicals; Hydroxides/metabolism; Liposomes/metabolism; Oxidation-Reduction; Peroxides/antagonists & inhibitors; Peroxides/metabolism; Superoxides/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Oxygen / Cataract / Lens, Crystalline Type of study: Diagnostic_studies / Screening_studies Limits: Animals Language: En Journal: Ophthalmic Res Year: 1988 Document type: Article Affiliation country: France Country of publication: Switzerland

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