Simultaneous in vitro generation of CD8 and CD4 T cells specific to three universal tumor associated antigens of WT1, survivin and TERT and adoptive T cell transfer for the treatment of acute myeloid leukemia.

Sohn, Hyun-Jung; Lee, Ji Yoon; Lee, Hyun-Joo; Sohn, Dae-Hee; Cho, Hyun-Il; Kim, Hee-Je; Kim, Tai-Gyu

Sohn, Hyun-Jung; Lee, Ji Yoon; Lee, Hyun-Joo; Sohn, Dae-Hee; Cho, Hyun-Il; Kim, Hee-Je; Kim, Tai-Gyu.

Affiliation

Sohn HJ; Catholic Hematopoietic Stem Cell Bank, The Catholic University of Korea, Seoul, Korea.
Lee JY; ViGenCell Inc., Seoul, Korea.
Lee HJ; Leukemia Research Institute, Seoul St. Mary`s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Sohn DH; Department of Biomedical Laboratory Science, College of Health Sciences, Sangji University, Wonju, Korea.
Cho HI; Catholic Hematopoietic Stem Cell Bank, The Catholic University of Korea, Seoul, Korea.
Kim HJ; ViGenCell Inc., Seoul, Korea.
Kim TG; Departments of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Oncotarget ; 8(27): 44059-44072, 2017 Jul 04.

Article in En | MEDLINE | ID: mdl-28477011

Subject(s)

Adoptive Transfer; CD4-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/immunology; Inhibitor of Apoptosis Proteins/immunology; Leukemia, Myeloid, Acute/immunology; Leukemia, Myeloid, Acute/therapy; Telomerase/immunology; WT1 Proteins/immunology; Animals; Antigens, Neoplasm/immunology; CD4-Positive T-Lymphocytes/metabolism; CD8-Positive T-Lymphocytes/metabolism; Dendritic Cells/immunology; Dendritic Cells/metabolism; Disease Models, Animal; Gene Expression; HLA-A Antigens/immunology; Humans; Inhibitor of Apoptosis Proteins/genetics; Interferon-gamma/metabolism; Leukemia, Myeloid, Acute/pathology; Mice; Survivin; T-Cell Antigen Receptor Specificity/immunology; Telomerase/genetics; Transfection; WT1 Proteins/genetics; Xenograft Model Antitumor Assays

Key words

Wilms' tumor protein 1; adoptive T cell therapy; dendritic cells; survivin; telomerase reverse transcriptase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / CD4-Positive T-Lymphocytes / CD8-Positive T-Lymphocytes / Telomerase / Adoptive Transfer / WT1 Proteins / Inhibitor of Apoptosis Proteins Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Oncotarget Year: 2017 Document type: Article Country of publication: United States

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