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A dual agonist of farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice.
Wang, Xiaoxin X; Luo, Yuhuan; Wang, Dong; Adorini, Luciano; Pruzanski, Mark; Dobrinskikh, Evgenia; Levi, Moshe.
Affiliation
  • Wang XX; Division of Renal Diseases and Hypertension, Department of Medicine, Denver Veterans Affairs Medical Center and University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
  • Luo Y; Division of Renal Diseases and Hypertension, Department of Medicine, Denver Veterans Affairs Medical Center and University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
  • Wang D; Division of Renal Diseases and Hypertension, Department of Medicine, Denver Veterans Affairs Medical Center and University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
  • Adorini L; Intercept Pharmaceuticals, New York, New York 10001.
  • Pruzanski M; Intercept Pharmaceuticals, New York, New York 10001.
  • Dobrinskikh E; Division of Renal Diseases and Hypertension, Department of Medicine, Denver Veterans Affairs Medical Center and University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
  • Levi M; Division of Renal Diseases and Hypertension, Department of Medicine, Denver Veterans Affairs Medical Center and University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045. Electronic address: Moshe.Levi@ucdenver.edu.
J Biol Chem ; 292(29): 12018-12024, 2017 07 21.
Article in En | MEDLINE | ID: mdl-28596381

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Bile Acids and Salts / Anti-Inflammatory Agents, Non-Steroidal / Receptors, Cytoplasmic and Nuclear / Receptors, G-Protein-Coupled / Renal Insufficiency / Kidney Language: En Journal: J Biol Chem Year: 2017 Document type: Article Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Bile Acids and Salts / Anti-Inflammatory Agents, Non-Steroidal / Receptors, Cytoplasmic and Nuclear / Receptors, G-Protein-Coupled / Renal Insufficiency / Kidney Language: En Journal: J Biol Chem Year: 2017 Document type: Article Country of publication: United States