Your browser doesn't support javascript.
loading
Methylprednisolone as a memory enhancer in rats: Effects on aversive memory, long-term potentiation and calcium influx.
de Vargas, Liane da Silva; Gonçalves, Rithiele; Lara, Marcus Vinícius S; Costa-Ferro, Zaquer S M; Salamoni, Simone Denise; Domingues, Michelle Flores; Piovesan, Angela Regina; de Assis, Dênis Reis; Vinade, Lucia; Corrado, Alexandre P; Alves-Do-Prado, Wilson; Correia-de-Sá, Paulo; da Costa, Jaderson Costa; Izquierdo, Ivan; Dal Belo, Cháriston A; Mello-Carpes, Pâmela B.
Affiliation
  • de Vargas LDS; Physiology Research Group, Federal University of Pampa, Uruguaiana, RS, Brazil.
  • Gonçalves R; Physiology Research Group, Federal University of Pampa, Uruguaiana, RS, Brazil.
  • Lara MVS; Physiology Research Group, Federal University of Pampa, Uruguaiana, RS, Brazil.
  • Costa-Ferro ZSM; Laboratory of Neuroscience, Brain Institute of Rio Grande do Sul, InsCer, PUCRS, Porto Alegre, RS, Brazil.
  • Salamoni SD; Laboratory of Neuroscience, Brain Institute of Rio Grande do Sul, InsCer, PUCRS, Porto Alegre, RS, Brazil.
  • Domingues MF; Graduate Program in Cell and Molecular Biology, Center of Biotechnology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Laboratory of Neurotoxins, Laneurotox, Brain Institute of Rio Grande do Sul, InsCer, PUCRS, Porto Alegre, RS, Brazil.
  • Piovesan AR; Graduate Program in Cell and Molecular Biology, Center of Biotechnology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Laboratory of Neurotoxins, Laneurotox, Brain Institute of Rio Grande do Sul, InsCer, PUCRS, Porto Alegre, RS, Brazil.
  • de Assis DR; Laboratory of Neuroscience, Brain Institute of Rio Grande do Sul, InsCer, PUCRS, Porto Alegre, RS, Brazil.
  • Vinade L; Laboratory of Neurobiology and Toxinology, Lanetox, Federal University of Pampa, São Gabriel, RS, Brazil.
  • Corrado AP; Department of Pharmacology, FMRP, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • Alves-Do-Prado W; Department of Pharmacology and Therapeutics, State University of Maringa, PR, Brazil.
  • Correia-de-Sá P; Laboratory of Pharmacology and Neurobiology, Center for Drug Discovery and Innovative Medicines (MedInUP), Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Portugal.
  • da Costa JC; Laboratory of Neuroscience, Brain Institute of Rio Grande do Sul, InsCer, PUCRS, Porto Alegre, RS, Brazil.
  • Izquierdo I; Centre of Memory, Brain Institute of Rio Grande do Sul, InsCer, PUCRS, Porto Alegre, RS, Brazil.
  • Dal Belo CA; Laboratory of Neurobiology and Toxinology, Lanetox, Federal University of Pampa, São Gabriel, RS, Brazil.
  • Mello-Carpes PB; Physiology Research Group, Federal University of Pampa, Uruguaiana, RS, Brazil. Electronic address: pamelacarpes@unipampa.edu.br.
Brain Res ; 1670: 44-51, 2017 Sep 01.
Article in En | MEDLINE | ID: mdl-28606783
It is well recognized that stress or glucocorticoids hormones treatment can modulate memory performance in both directions, either impairing or enhancing it. Despite the high number of studies aiming at explaining the effects of glucocorticoids on memory, this has not yet been completely elucidated. Here, we demonstrate that a low daily dose of methylprednisolone (MP, 5mg/kg, i.p.) administered for 10-days favors aversive memory persistence in adult rats, without any effect on the exploring behavior, locomotor activity, anxiety levels and pain perception. Enhanced performance on the inhibitory avoidance task was correlated with long-term potentiation (LTP), a phenomenon that was strengthen in hippocampal slices of rats injected with MP (5mg/kg) during 10days. Additionally, in vitro incubation with MP (30-300µM) concentration-dependently increased intracellular [Ca2+]i in cultured hippocampal neurons depolarized by KCl (35mM). In conclusion, a low daily dose of MP for 10days may promote aversive memory persistence in rats.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Methylprednisolone / Long-Term Potentiation / Memory Limits: Animals Language: En Journal: Brain Res Year: 2017 Document type: Article Affiliation country: Brazil Country of publication: Netherlands
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Methylprednisolone / Long-Term Potentiation / Memory Limits: Animals Language: En Journal: Brain Res Year: 2017 Document type: Article Affiliation country: Brazil Country of publication: Netherlands