Synthesis and evaluation of arylamidine derivatives for new antimicrobial and cytotoxic activities.
An Acad Bras Cienc
; 89(2): 1051-1059, 2017.
Article
in En
| MEDLINE
| ID: mdl-28640352
A series of arylamidines 3a-j was designed, synthesized and investigated for antimicrobial activity. Structures of the compounds were confirmed by IR, 1H-NMR and 13C-NMR and a 2D spectroscopic study was performed. A preliminary screening of the antimicrobial tests clearly showed that three out of ten arylamidines, viz, 3f, 3g and 3i, were effective against all the gram-negative bacteria: Klebsiella pneumoniae, Pseudomonas aeruginosa and Salmonella enteric; and against the yeast, candida albicans. Further, the Minimum Inhibitory Concentrations (MIC) against the bacteria and yeast were determined. All compounds 3a-d, 3f, 3g, 3i and 3j were also investigated for their low cytotoxic effects on tested cell lines. Compounds 3d and 3f were the most effective derivatives against HL-60 and HEp-2 cells, respectively, with IC50 value (2µg/mL), and low normal cells toxicity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Candida albicans
/
Amidines
/
Gram-Negative Bacteria
/
Anti-Infective Agents
Limits:
Humans
Language:
En
Journal:
An Acad Bras Cienc
Year:
2017
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil