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Gemcitabine treatment induces endoplasmic reticular (ER) stress and subsequently upregulates urokinase plasminogen activator (uPA) to block mitochondrial-dependent apoptosis in Panc-1 cancer stem-like cells (CSCs).
Wang, Li; Zhang, Yi; Wang, Weiguo; Zhu, Yunjie; Chen, Yang; Tian, Bole.
Affiliation
  • Wang L; Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China.
  • Zhang Y; Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China.
  • Wang W; Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China.
  • Zhu Y; Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China.
  • Chen Y; Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China.
  • Tian B; Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China.
PLoS One ; 12(8): e0184110, 2017.
Article in En | MEDLINE | ID: mdl-28854261
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Neoplastic Stem Cells / Urokinase-Type Plasminogen Activator / Deoxycytidine / Endoplasmic Reticulum Stress / Mitochondria / Antimetabolites, Antineoplastic Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2017 Document type: Article Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Neoplastic Stem Cells / Urokinase-Type Plasminogen Activator / Deoxycytidine / Endoplasmic Reticulum Stress / Mitochondria / Antimetabolites, Antineoplastic Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2017 Document type: Article Country of publication: United States