Detection of Regional Variation in Selection Intensity within Protein-Coding Genes Using DNA Sequence Polymorphism and Divergence.

Zhao, Zi-Ming; Campbell, Michael C; Li, Ning; Lee, Daniel S W; Zhang, Zhang; Townsend, Jeffrey P

Zhao, Zi-Ming; Campbell, Michael C; Li, Ning; Lee, Daniel S W; Zhang, Zhang; Townsend, Jeffrey P.

Affiliation

Zhao ZM; Department of Biostatistics, Yale University, New Haven, CT.
Campbell MC; Department of Biostatistics, Yale University, New Haven, CT.
Li N; Department of Biology, Howard University, Washington, DC.
Lee DSW; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT.
Zhang Z; Department of Biostatistics, Yale University, New Haven, CT.
Townsend JP; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.

Mol Biol Evol ; 34(11): 3006-3022, 2017 Nov 01.

Article in En | MEDLINE | ID: mdl-28962009

Subject(s)

Genetic Variation/genetics; Sequence Analysis, DNA/methods; Sequence Analysis, DNA/statistics & numerical data; Algorithms; Amino Acid Substitution/genetics; Animals; Cluster Analysis; Evolution, Molecular; Exons/genetics; Humans; Models, Genetic; Open Reading Frames/genetics; Polymorphism, Genetic/genetics; Polymorphism, Single Nucleotide/genetics; Selection, Genetic/genetics

Key words

Poisson Random Field; divergence; human evolution; model averaged site selection; natural selection; polymorphism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Variation / Sequence Analysis, DNA Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Biol Evol Journal subject: BIOLOGIA MOLECULAR Year: 2017 Document type: Article Country of publication: United States

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