Propofol enhances BCR-ABL TKIs' inhibitory effects in chronic myeloid leukemia through Akt/mTOR suppression.

Tan, Zhimin; Peng, Aixia; Xu, Jingwen; Ouyang, Mingwen

Tan, Zhimin; Peng, Aixia; Xu, Jingwen; Ouyang, Mingwen.

Affiliation

Tan Z; Department of Anesthesiology, Shenzhen Hospital, Southern Medical University, Xinhu Road No.1333, Bao'an district, Shenzhen, 518100, Guangdong province, China.
Peng A; Department of Oncology, Shenzhen Hospital, Southern Medical University, Xinhu Road No.1333, Bao'an district, Shenzhen, 518100, Guangdong province, China.
Xu J; Department of Anesthesiology, Fifth Affiliated Hospital, Southern Medical University, Congcheng Road No. 566, Conghua district, Guangzhou, Guangdong province, 510900, China.
Ouyang M; Department of Anesthesiology, Fifth Affiliated Hospital, Southern Medical University, Congcheng Road No. 566, Conghua district, Guangzhou, Guangdong province, 510900, China. ouyangmw119@163.com.

BMC Anesthesiol ; 17(1): 132, 2017 Sep 29.

Article in En | MEDLINE | ID: mdl-28962554

Subject(s)

Fusion Proteins, bcr-abl/therapeutic use; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy; Propofol/pharmacology; Protein Kinase Inhibitors/therapeutic use; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; TOR Serine-Threonine Kinases/antagonists & inhibitors; Animals; Cell Proliferation/drug effects; Cell Proliferation/physiology; Dose-Response Relationship, Drug; Fusion Proteins, bcr-abl/pharmacology; Humans; Hypnotics and Sedatives/pharmacology; Hypnotics and Sedatives/therapeutic use; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism; Male; Mice; Mice, Inbred NOD; Mice, SCID; Propofol/therapeutic use; Protein Kinase Inhibitors/pharmacology; Proto-Oncogene Proteins c-akt/metabolism; Random Allocation; TOR Serine-Threonine Kinases/metabolism; Tumor Burden/drug effects; Tumor Burden/physiology; Xenograft Model Antitumor Assays/methods

Key words

Akt/mTOR; Drug repurposing; Leukemia; Propofol

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Propofol / Fusion Proteins, bcr-abl / Protein Kinase Inhibitors / Proto-Oncogene Proteins c-akt / TOR Serine-Threonine Kinases Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: BMC Anesthesiol Year: 2017 Document type: Article Affiliation country: China Country of publication: United kingdom

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