DADLE enhances viability and anti-inflammatory effect of human MSCs subjected to 'serum free' apoptotic condition in part via the DOR/PI3K/AKT pathway.

Reddy, L Vinod Kumar; Sen, Dwaipayan

Reddy, L Vinod Kumar; Sen, Dwaipayan.

Affiliation

Reddy LVK; Cellular and Molecular Therapeutics Laboratory, Centre for Biomaterials, Cellular and Molecular Theranostics, Vellore Institute of Technology (VIT) University, Vellore 632014, Tamil Nadu, India,. Electronic address: vinodkumarreddy.l@vit.ac.in.
Sen D; Cellular and Molecular Therapeutics Laboratory, Centre for Biomaterials, Cellular and Molecular Theranostics, Vellore Institute of Technology (VIT) University, Vellore 632014, Tamil Nadu, India,. Electronic address: dwaipayan.sen@vit.ac.in.

Life Sci ; 191: 195-204, 2017 Dec 15.

Article in En | MEDLINE | ID: mdl-29054455

Subject(s)

Analgesics, Opioid/pharmacology; Anti-Inflammatory Agents/pharmacology; Cell Survival/drug effects; Enkephalin, Leucine-2-Alanine/pharmacology; Mesenchymal Stem Cells/drug effects; Signal Transduction/drug effects; Apoptosis/drug effects; Cell Line; Cytoprotection/drug effects; Humans; Mesenchymal Stem Cells/cytology; Mesenchymal Stem Cells/immunology; Phosphatidylinositol 3-Kinases/immunology; Proto-Oncogene Proteins c-akt/immunology; Receptors, Opioid, delta/agonists; Receptors, Opioid, delta/immunology

Key words

Anti-inflammatory cytokines; Cell survival; DADLE; MSCs; PI3K/Akt signaling

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Cell Survival / Enkephalin, Leucine-2-Alanine / Mesenchymal Stem Cells / Analgesics, Opioid / Anti-Inflammatory Agents Limits: Humans Language: En Journal: Life Sci Year: 2017 Document type: Article Country of publication: Netherlands

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