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A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys.
St Andre, Michael; Johnson, Mark; Bansal, Prashant N; Wellen, Jeremy; Robertson, Andrew; Opsahl, Alan; Burch, Peter M; Bialek, Peter; Morris, Carl; Owens, Jane.
Affiliation
  • St Andre M; Rare Disease Research Unit, Pfizer Inc., 610 Main Street, Cambridge, MA, 02139, USA. Michael.StAndre@pfizer.com.
  • Johnson M; NIGMS Training Program in Biomolecular Pharmacology, Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA. Michael.StAndre@pfizer.com.
  • Bansal PN; Rare Disease Research Unit, Pfizer Inc., 610 Main Street, Cambridge, MA, 02139, USA.
  • Wellen J; Early Clinical Development, Pfizer Inc., Cambridge, MA, USA.
  • Robertson A; Present Address: PAREXEL Informatics, Billerica, MA, USA.
  • Opsahl A; Early Clinical Development, Pfizer Inc., Cambridge, MA, USA.
  • Burch PM; Investigative Pathology, Pfizer Inc., Groton, CT, USA.
  • Bialek P; Investigative Pathology, Pfizer Inc., Groton, CT, USA.
  • Morris C; Research and Development Drug Safety, Pfizer Inc., Groton, CT, USA.
  • Owens J; Present Address: Summit Therapeutics, Cambridge, MA, USA.
Skelet Muscle ; 7(1): 25, 2017 11 09.
Article in En | MEDLINE | ID: mdl-29121992
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Muscle, Skeletal / Muscular Dystrophy, Duchenne / Muscle Strength / Myostatin / Antibodies / Muscle Contraction Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Skelet Muscle Year: 2017 Document type: Article Affiliation country: United States Country of publication: United kingdom
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Muscle, Skeletal / Muscular Dystrophy, Duchenne / Muscle Strength / Myostatin / Antibodies / Muscle Contraction Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Skelet Muscle Year: 2017 Document type: Article Affiliation country: United States Country of publication: United kingdom