Naringin prevents the inhibition of intestinal Ca2+ absorption induced by a fructose rich diet.
Arch Biochem Biophys
; 636: 1-10, 2017 12 15.
Article
in En
| MEDLINE
| ID: mdl-29122589
This study tries to elucidate the mechanisms by which fructose rich diets (FRD) inhibit the rat intestinal Ca2+ absorption, and determine if any or all underlying alterations are prevented by naringin (NAR). Male rats were divided into: 1) controls, 2) treated with FRD, 3) treated with FRD and NAR. The intestinal Ca2+ absorption and proteins of the transcellular and paracellular Ca2+ pathways were measured. Oxidative/nitrosative stress and inflammation parameters were evaluated. FRD rats showed inhibition of the intestinal Ca2+ absorption and decrease in the protein expression of molecules of both Ca2+ pathways, which were blocked by NAR. FRD rats showed an increase in the superoxide anion, a decrease in the glutathione and in the enzymatic activities of the antioxidant system, as well as an increase in the NO content and in the nitrotyrosine content of proteins. They also exhibited an increase in both IL-6 and nuclear NF-κB. All these changes were prevented by NAR. In conclusion, FRD inhibit both pathways of the intestinal Ca2+ absorption due to the oxidative/nitrosative stress and inflammation. Since NAR prevents the oxidative/nitrosative stress and inflammation, it might be a drug to avoid alteration in the intestinal Ca2+ absorption caused by FRD.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dietary Carbohydrates
/
Calcium
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Calcium Signaling
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Flavanones
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Fructose
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Intestinal Absorption
Limits:
Animals
Language:
En
Journal:
Arch Biochem Biophys
Year:
2017
Document type:
Article
Affiliation country:
Argentina
Country of publication:
United States