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The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD.
Fu, Chengzhang; Sikandar, Asfandyar; Donner, Jannik; Zaburannyi, Nestor; Herrmann, Jennifer; Reck, Michael; Wagner-Döbler, Irene; Koehnke, Jesko; Müller, Rolf.
Affiliation
  • Fu C; Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarland University, Campus E8.1, 66123, Saarbrücken, Germany.
  • Sikandar A; Helmholtz Institute for Pharmaceutical Research Saarland, Workgroup Structural Biology of Biosynthetic Enzymes, Helmholtz Centre for Infection Research, Saarland University, Campus E8.1, 66123, Saarbrücken, Germany.
  • Donner J; Helmholtz Center for Infection Research (HZI), Group Microbial Communication, 38124, Braunschweig, Germany.
  • Zaburannyi N; Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarland University, Campus E8.1, 66123, Saarbrücken, Germany.
  • Herrmann J; Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarland University, Campus E8.1, 66123, Saarbrücken, Germany.
  • Reck M; German Centre for Infection Research (DZIF), Partner Site Hannover, 38124, Braunschweig, Germany.
  • Wagner-Döbler I; Helmholtz Center for Infection Research (HZI), Group Microbial Communication, 38124, Braunschweig, Germany.
  • Koehnke J; Helmholtz Center for Infection Research (HZI), Group Microbial Communication, 38124, Braunschweig, Germany.
  • Müller R; Helmholtz Institute for Pharmaceutical Research Saarland, Workgroup Structural Biology of Biosynthetic Enzymes, Helmholtz Centre for Infection Research, Saarland University, Campus E8.1, 66123, Saarbrücken, Germany. jesko.koehnke@helmholtz-hzi.de.
Nat Commun ; 8(1): 1529, 2017 11 16.
Article in En | MEDLINE | ID: mdl-29142318
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Biological Products / Myxococcales / Macrolides / Formate-Tetrahydrofolate Ligase / Aminohydrolases / Methylenetetrahydrofolate Dehydrogenase (NADP) / Multienzyme Complexes Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2017 Document type: Article Affiliation country: Germany Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Biological Products / Myxococcales / Macrolides / Formate-Tetrahydrofolate Ligase / Aminohydrolases / Methylenetetrahydrofolate Dehydrogenase (NADP) / Multienzyme Complexes Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2017 Document type: Article Affiliation country: Germany Country of publication: United kingdom