Information propagation in a noisy gene cascade.
Phys Rev E
; 96(1-1): 012403, 2017 Jul.
Article
in En
| MEDLINE
| ID: mdl-29347170
We use information theory to study the information transmission through a simple gene cascade where the product of an unregulated gene regulates the expression activity of a cooperative genetic switch. While the input signal is provided by the upstream gene with two states, we consider that the expression of downstream gene is controlled by a cis-regulatory system with three binding sites for the regulator product, which can bind cooperatively. By computing exactly the associated probability distributions, we estimate information transmission thought the mutual information measure. We found that the mutual information associated with unimodal input signal is lower than the associated with bimodal inputs. We also observe that mutual information presents a maximum in the cooperativity intensity, and the position of this maximum depends on the kinetic rates of the promoter. Furthermore, we found that the bursting dynamics of the input signal can enhance the information transmission capacity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gene Expression Regulation
/
Genes
/
Models, Genetic
Type of study:
Prognostic_studies
Language:
En
Journal:
Phys Rev E
Year:
2017
Document type:
Article
Affiliation country:
Argentina
Country of publication:
United States