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Epstein-Barr virus infection of infants: implications of early age of infection on viral control and risk for Burkitt lymphoma.
Rochford, Rosemary.
Affiliation
  • Rochford R; Department of Immunology and Microbiology University of Colorado School of Medicine, Aurora, CO, USA. Electronic address: rosemary.rochford@ucdenver.edu.
Bol Med Hosp Infant Mex ; 73(1): 41-46, 2016.
Article in En | MEDLINE | ID: mdl-29421232
Since its first description by Denis Burkitt, endemic Burkitt's lymphoma (BL), the most common childhood cancer in sub-Saharan Africa, has led scientists to search for clues to the origins of this malignancy. The discovery of Epstein-Barr virus (EBV) in BL cells over 50 years ago led to extensive sero-epidemiology studies and revealed that rather than being a virus restricted to areas where BL is endemic, EBV is ubiquitous in the world's population with an estimated greater than 90% of adults worldwide infected. A second pathogen, Plasmodium falciparum (P. falciparum) malaria is also linked to BL. In this review, we will discuss recent studies that indicate a role for P. falciparum malaria in dysregulating EBV infection, and increasing the risk for BL in children living where P. falciparum malaria transmission is high.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Etiology_studies / Risk_factors_studies Language: En Journal: Bol Med Hosp Infant Mex Year: 2016 Document type: Article Country of publication: Mexico

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Etiology_studies / Risk_factors_studies Language: En Journal: Bol Med Hosp Infant Mex Year: 2016 Document type: Article Country of publication: Mexico