Reserpine Induces Apoptosis and Cell Cycle Arrest in Hormone Independent Prostate Cancer Cells through Mitochondrial Membrane Potential Failure.

Ramamoorthy, Manjula Devi; Kumar, Ashok; Ayyavu, Mahesh; Dhiraviam, Kannan Narayanan

Ramamoorthy, Manjula Devi; Kumar, Ashok; Ayyavu, Mahesh; Dhiraviam, Kannan Narayanan.

Affiliation

Ramamoorthy MD; Department of Plant Biotechnology, School of Biotechnology, Madurai Kamaraj University, Madurai-625021, Tamilnadu, India.
Kumar A; Department of Plant Biotechnology, School of Biotechnology, Madurai Kamaraj University, Madurai-625021, Tamilnadu, India.
Ayyavu M; School of Biological Sciences, Madurai Kamaraj University, Madurai-625021, Tamilnadu, India.
Dhiraviam KN; Department of Plant Biotechnology, School of Biotechnology, Madurai Kamaraj University, Madurai-625021, Tamilnadu, India.

Anticancer Agents Med Chem ; 18(9): 1313-1322, 2018.

Article in En | MEDLINE | ID: mdl-29424320

Subject(s)

Antineoplastic Agents, Phytogenic/pharmacology; Apoptosis/drug effects; Cell Cycle Checkpoints/drug effects; Membrane Potential, Mitochondrial/drug effects; Prostatic Neoplasms/drug therapy; Reserpine/pharmacology; Antineoplastic Agents, Phytogenic/chemistry; Humans; Male; PC-3 Cells; Prostatic Neoplasms/metabolism; Rauwolfia/chemistry; Reserpine/chemistry

Key words

Rauwolfia serpentina; caspase; cell cycle; mitochondrial membrane; molecular docking; reactive oxygen species.

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Reserpine / Apoptosis / Membrane Potential, Mitochondrial / Cell Cycle Checkpoints / Antineoplastic Agents, Phytogenic Limits: Humans / Male Language: En Journal: Anticancer Agents Med Chem Journal subject: ANTINEOPLASICOS / QUIMICA Year: 2018 Document type: Article Affiliation country: India Country of publication: Netherlands

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