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Antibacterial and immunomodulatory activities of bovine lactoferrin against Escherichia coli O157:H7 infections in cattle.
Kieckens, Evelien; Rybarczyk, Joanna; Cox, Eric; Vanrompay, Daisy.
Affiliation
  • Kieckens E; Laboratory of Immunology and Animal Biotechnology, Department of Animal Production, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000, Ghent, Belgium.
  • Rybarczyk J; Laboratory of Immunology and Animal Biotechnology, Department of Animal Production, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000, Ghent, Belgium.
  • Cox E; Laboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.
  • Vanrompay D; Laboratory of Immunology and Animal Biotechnology, Department of Animal Production, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000, Ghent, Belgium. Daisy.Vanrompay@UGent.be.
Biometals ; 31(3): 321-330, 2018 06.
Article in En | MEDLINE | ID: mdl-29442205
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a zoonotic pathogen that causes food-borne disease in humans ranging from watery diarrhea to bloody diarrhea and severe hemorrhagic colitis, renal failure and hemolytic uremic syndrome. Cattle, the most important source of E. coli O157:H7 transmission to humans, harbor the bacteria in their gastrointestinal tract without showing clinical symptoms. Prevention of E. coli O157:H7 infections in ruminants could diminish the public health risk. However, there is no specific treatment available nor a vaccine or a therapeutic agent which completely prevents E. coli O157:H7 infections in cattle. This paper provides an overview of latest research data on eradicating enterohemorrhagic E. coli O157:H7 in ruminants by use of bovine lactoferrin administration. The article provides insights into the anti-microbial and immunomodulatory activities of bovine lactoferrin against E. coli O157:H7 infections in cattle.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Escherichia coli O157 / Escherichia coli Infections / Lactoferrin / Anti-Bacterial Agents Limits: Animals / Humans Language: En Journal: Biometals Journal subject: BIOQUIMICA Year: 2018 Document type: Article Affiliation country: Belgium Country of publication: Netherlands

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Escherichia coli O157 / Escherichia coli Infections / Lactoferrin / Anti-Bacterial Agents Limits: Animals / Humans Language: En Journal: Biometals Journal subject: BIOQUIMICA Year: 2018 Document type: Article Affiliation country: Belgium Country of publication: Netherlands