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Aerobic exercise inhibits obesity-induced respiratory phenotype.
Aquino-Junior, Jefferson Comin Jonco; MacKenzie, BreAnne; Almeida-Oliveira, Ana Roberta; Martins, Ana Carolina; Oliveira-Junior, Manoel Carneiro; Britto, Auriléa Aparecida; Arantes-Costa, Fernanda Magalhaes; Damaceno-Rodrigues, Nilsa Regina; Caldini, Elia Garcia; de Oliveira, Ana Paula Ligeiro; Guadagnini, Dioze; Leiria, Luiz Osorio; Ricardo, Djalma Rabelo; Abdalla Saad, Mario Jose; Vieira, Rodolfo Paula.
Affiliation
  • Aquino-Junior JCJ; Nove de Julho University, Rua Vergueiro 235/249, São Paulo, SP 01504-001, Brazil.
  • MacKenzie B; Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), Rua Pedro Ernesto 240, Sao José dos Campos, SP 12245-520, Brazil.
  • Almeida-Oliveira AR; Nove de Julho University, Rua Vergueiro 235/249, São Paulo, SP 01504-001, Brazil.
  • Martins AC; Universidade Brasil, Rua Carolina Fonseca, 584 - Itaquera, São Paulo, SP 08230-030, Brazil.
  • Oliveira-Junior MC; Nove de Julho University, Rua Vergueiro 235/249, São Paulo, SP 01504-001, Brazil; Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), Rua Pedro Ernesto 240, Sao José dos Campos, SP 12245-520, Brazil.
  • Britto AA; Nove de Julho University, Rua Vergueiro 235/249, São Paulo, SP 01504-001, Brazil.
  • Arantes-Costa FM; Laboratory of Experimental Therapeutics (LIM 20), School of Medicine, University of Sao Paulo (USP), Avenida Doutor Arnaldo 455, Cerqueira Cesar, Sao Paulo, SP 01246-903, Brazil.
  • Damaceno-Rodrigues NR; Laboratory of Cellular Biology (LIM 59), School of Medicine, University of Sao Paulo (USP), Avenida Doutor Arnaldo 455, Cerqueira Cesar, Sao Paulo, SP 01246-903, Brazil.
  • Caldini EG; Laboratory of Cellular Biology (LIM 59), School of Medicine, University of Sao Paulo (USP), Avenida Doutor Arnaldo 455, Cerqueira Cesar, Sao Paulo, SP 01246-903, Brazil.
  • de Oliveira APL; Nove de Julho University, Rua Vergueiro 235/249, São Paulo, SP 01504-001, Brazil; Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), Rua Pedro Ernesto 240, Sao José dos Campos, SP 12245-520, Brazil.
  • Guadagnini D; Department of Internal Medicine, State University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo 126, Cidade Universitária, Campinas, SP 13083-887, Brazil.
  • Leiria LO; Department of Internal Medicine, State University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo 126, Cidade Universitária, Campinas, SP 13083-887, Brazil.
  • Ricardo DR; School of Medical Sciences of Sao Jose dos Campos Humanitas, Avenida Brigadeiro Faria Lima 811, Sao José dos Campos, SP 12227-000, Brazil.
  • Abdalla Saad MJ; Department of Internal Medicine, State University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo 126, Cidade Universitária, Campinas, SP 13083-887, Brazil.
  • Vieira RP; Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), Rua Pedro Ernesto 240, Sao José dos Campos, SP 12245-520, Brazil; School of Medical Sciences of Sao Jose dos Campos Humanitas, Avenida Brigadeiro Faria Lima 811, Sao José dos Campos, SP 12227-000, Brazil; Un
Cytokine ; 104: 46-52, 2018 04.
Article in En | MEDLINE | ID: mdl-29454302
PURPOSE: Obesity results in decreased lung function and increased inflammation. Moderate aerobic exercise (AE) reduced lung inflammation and remodeling in a variety of respiratory disease models. Therefore, this study investigated whether AE can attenuate a diet-induced obesity respiratory phenotype; including airway hyper-responsiveness (AHR), remodeling and inflammation. METHODS: Sixty C57Bl/6 male mice were distributed into four groups: control lean (CL), exercise lean (EL), obese (O) and obese exercise (OE) groups (2 sets of 7 and 8 mice per group; n = 15). A classical model of diet-induced obesity (DIO) over 12 weeks was used. AE was performed 60 min/day, 5 days/week for 5 weeks. Airway hyperresponsiveness (AHR), lung inflammation and remodeling, adipokines and cytokines in bronchoalveolar lavage (BAL) was determined. RESULTS: A high fat diet over 18 weeks significantly increased body weight (p < .0001). Five weeks of AE significantly reduced both AHR and pulmonary inflammation. AHR in obese mice that exercised was reduced at the basal level (p < .05), vehicle (PBS) (p < .05), 6.25 MCh mg/mL (p < .05), 12.5 MCh mg/mL (p < .01), 25 MCh mg/mL (p < .01) and 50 MCh mg/mL (p < .05). Collagen (p < .001) and elastic (p < .001) fiber deposition in airway wall and also smooth muscle thickness (p < .001) were reduced. The number of neutrophils (p < .001), macrophages (p < .001) and lymphocytes (p < .01) were reduced in the peribronchial space as well as in the BAL: lymphocytes (p < .01), macrophages (p < .01), neutrophils (p < .001). AE reduced obesity markers leptin (p < .001), IGF-1 (p < .01) and VEGF (p < .001), while increased adiponectin (p < .01) in BAL. AE also reduced pro-inflammatory cytokines in the BAL: IL-1ß (p < .001), IL-12p40 (p < .001), IL-13 (p < .01), IL-17 (p < .001, IL-23 (p < .05) and TNF-alpha (p < .05), and increased anti-inflammatory cytokine IL-10 (p < .05). CONCLUSIONS: Aerobic exercise reduces high fat diet-induced obese lung phenotype (AHR, pulmonary remodeling and inflammation), involving anti-inflammatory cytokine IL-10 and adiponectin.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Physical Conditioning, Animal / Respiratory Hypersensitivity / Obesity Limits: Animals Language: En Journal: Cytokine Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Document type: Article Affiliation country: Brazil Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Physical Conditioning, Animal / Respiratory Hypersensitivity / Obesity Limits: Animals Language: En Journal: Cytokine Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Document type: Article Affiliation country: Brazil Country of publication: United kingdom