Chrysophanol Relieves Cognition Deficits and Neuronal Loss Through Inhibition of Inflammation in Diabetic Mice.

Chu, Xu; Zhou, Shuhu; Sun, Ran; Wang, Lin; Xing, Chunye; Liang, Ruqing; Kong, Qingxia

Chu, Xu; Zhou, Shuhu; Sun, Ran; Wang, Lin; Xing, Chunye; Liang, Ruqing; Kong, Qingxia.

Affiliation

Chu X; Department of Neurology, Affiliated Hospital of Jining Medical University, 89 Guhuai Road, Jining, 272000, Shandong, People's Republic of China.
Zhou S; Department of Neurology, Affiliated Hospital of Jining Medical University, 89 Guhuai Road, Jining, 272000, Shandong, People's Republic of China.
Sun R; Department of Neurology, Affiliated Hospital of Jining Medical University, 89 Guhuai Road, Jining, 272000, Shandong, People's Republic of China.
Wang L; Department of Neurology, Affiliated Hospital of Jining Medical University, 89 Guhuai Road, Jining, 272000, Shandong, People's Republic of China.
Xing C; Department of Neurology, Affiliated Hospital of Jining Medical University, 89 Guhuai Road, Jining, 272000, Shandong, People's Republic of China.
Liang R; Department of Neurology, Affiliated Hospital of Jining Medical University, 89 Guhuai Road, Jining, 272000, Shandong, People's Republic of China.
Kong Q; Department of Neurology, Affiliated Hospital of Jining Medical University, 89 Guhuai Road, Jining, 272000, Shandong, People's Republic of China. chuxu2016@sohu.com.

Neurochem Res ; 43(4): 972-983, 2018 Apr.

Article in En | MEDLINE | ID: mdl-29497904

Subject(s)

Anthraquinones/therapeutic use; CA3 Region, Hippocampal/drug effects; Cognitive Dysfunction/drug therapy; Diabetes Mellitus, Experimental/drug therapy; Neurons/drug effects; Animals; Anthraquinones/pharmacology; CA3 Region, Hippocampal/metabolism; CA3 Region, Hippocampal/pathology; Cell Count/methods; Cognitive Dysfunction/metabolism; Cognitive Dysfunction/pathology; Diabetes Mellitus, Experimental/metabolism; Diabetes Mellitus, Experimental/pathology; Inflammation/drug therapy; Inflammation/metabolism; Inflammation/pathology; Inflammation Mediators/antagonists & inhibitors; Inflammation Mediators/metabolism; Male; Maze Learning/drug effects; Maze Learning/physiology; Mice; Mice, Inbred ICR; Neurons/metabolism; Neurons/pathology

Key words

Astrocytes; Chrysophanol; Cognition dysfunction; Diabetic encephalopathy; Pro-inflammation cytokines

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anthraquinones / Diabetes Mellitus, Experimental / CA3 Region, Hippocampal / Cognitive Dysfunction / Neurons Limits: Animals Language: En Journal: Neurochem Res Year: 2018 Document type: Article Country of publication: United States

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