A Potential Bone-Targeting Hypotoxic Platinum(II) Complex with an Unusual Cytostatic Mechanism toward Osteosarcoma Cells.

Zhang, Zhenqin; Zhu, Zhenzhu; Luo, Cheng; Zhu, Chengcheng; Zhang, Changli; Guo, Zijian; Wang, Xiaoyong

Zhang, Zhenqin; Zhu, Zhenzhu; Luo, Cheng; Zhu, Chengcheng; Zhang, Changli; Guo, Zijian; Wang, Xiaoyong.

Affiliation

Zhang Z; School of Pharmacy , Nanjing Medical University , Nanjing 211166 , People's Republic of China.

Inorg Chem ; 57(6): 3315-3322, 2018 Mar 19.

Article in En | MEDLINE | ID: mdl-29513007

Subject(s)

Antineoplastic Agents/pharmacology; Coordination Complexes/pharmacology; Diphosphonates/pharmacology; Platinum/chemistry; Animals; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/chemistry; Antineoplastic Agents/toxicity; Apoptosis/drug effects; Cell Line, Tumor; Cisplatin/pharmacology; Coordination Complexes/chemical synthesis; Coordination Complexes/chemistry; Coordination Complexes/toxicity; DNA/chemistry; Diphosphonates/chemical synthesis; Diphosphonates/chemistry; Diphosphonates/toxicity; G1 Phase Cell Cycle Checkpoints/drug effects; Humans; Ligands; Male; Metabolic Networks and Pathways/drug effects; Mice, Inbred ICR; Molecular Structure; Osteosarcoma/drug therapy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Platinum / Diphosphonates / Coordination Complexes / Antineoplastic Agents Limits: Animals / Humans / Male Language: En Journal: Inorg Chem Year: 2018 Document type: Article Country of publication: United States

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