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A case-control study of breast cancer and hormonal contraception in Costa Rica.
Lee, N C; Rosero-Bixby, L; Oberle, M W; Grimaldo, C; Whatley, A S; Rovira, E Z.
Affiliation
  • Lee NC; Division of Reproductive Health, Centers for Disease Control, Atlanta, GA 30333.
J Natl Cancer Inst ; 79(6): 1247-54, 1987 Dec.
Article in En | MEDLINE | ID: mdl-2961909
ABSTRACT
PIP: Depot-medroxyprogesterone acetate (DMPA) is used by approximately 2 million women world-wide. In Costa Rica, by 1981 11% of the married women had used DMPA. Although no definitive link between the use of DMPA and the development of cancer has been found, the possibility has been recognized as one of the reasons for the U.S food and Drug Administration denying approval of the drug. Since 1977, the Ministry of Health in Costa Rica has sustained a national cancer registry. The accuracy of the reporting of the registry was studied by comparing a sampling of gynecologic cancer cases in the year 1983 to the national registry. In examination of the records, an elevated relative risk of breast cancer for DMPA users was found (2.6), and an elevated relative risk for women who had even used DMPA for a short period of time (2.3). The failure to interview 1/3 of the cases, differences in detection and the misclassification of DMPA use contributed cumulatively to the belief that a positive connection between breast cancer and DMPA use could otherwise be drawn. In contrast to the association found between DMPA ever use and breast cancer, no connection was found between OC use and the incidence of breast cancer. However, due to the small number of DMPA users recorded and the void of complete and accurate recorded information, the study results remain inconclusive.
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Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Contraceptives, Oral / Medroxyprogesterone Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Middle aged Country/Region as subject: America central / Costa rica Language: En Journal: J Natl Cancer Inst Year: 1987 Document type: Article Country of publication: United States
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Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Contraceptives, Oral / Medroxyprogesterone Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Middle aged Country/Region as subject: America central / Costa rica Language: En Journal: J Natl Cancer Inst Year: 1987 Document type: Article Country of publication: United States