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APR-246 reactivates mutant p53 by targeting cysteines 124 and 277.
Zhang, Qiang; Bykov, Vladimir J N; Wiman, Klas G; Zawacka-Pankau, Joanna.
Affiliation
  • Zhang Q; Department of Oncology and Pathology, Cancer Center Karolinska (CCK), Karolinska Institutet, SE-17176, Stockholm, Sweden.
  • Bykov VJN; Department of Oncology and Pathology, Cancer Center Karolinska (CCK), Karolinska Institutet, SE-17176, Stockholm, Sweden.
  • Wiman KG; Department of Oncology and Pathology, Cancer Center Karolinska (CCK), Karolinska Institutet, SE-17176, Stockholm, Sweden. Klas.Wiman@ki.se.
  • Zawacka-Pankau J; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, SE-17177, Stockholm, Sweden.
Cell Death Dis ; 9(5): 439, 2018 05 01.
Article in En | MEDLINE | ID: mdl-29670092
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aza Compounds / Tumor Suppressor Protein p53 / Bridged Bicyclo Compounds, Heterocyclic Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cell Death Dis Year: 2018 Document type: Article Affiliation country: Sweden
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aza Compounds / Tumor Suppressor Protein p53 / Bridged Bicyclo Compounds, Heterocyclic Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cell Death Dis Year: 2018 Document type: Article Affiliation country: Sweden