Some indazoles reduced the activity of human serum paraoxonase 1, an antioxidant enzyme: <i>in vitro</i> inhibition and molecular modeling studies.

Alim, Zuhal; Kiliç, Deryanur; Demir, Yeliz

Some indazoles reduced the activity of human serum paraoxonase 1, an antioxidant enzyme: in vitro inhibition and molecular modeling studies.

Alim, Zuhal; Kiliç, Deryanur; Demir, Yeliz.

Affiliation

Alim Z; Faculty of Science and Arts, Department of Chemistry, Ahi Evran University , Kirsehir , Turkey.
Kiliç D; Faculty of Science and Arts, Department of Chemistry, Aksaray University , Aksaray , Turkey.
Demir Y; Faculty of Sciences, Department of Chemistry, Biochemistry Division, Ataturk University , Erzurum , Turkey.

Arch Physiol Biochem ; 125(5): 387-395, 2019 Dec.

Article in En | MEDLINE | ID: mdl-29741961

Subject(s)

Antioxidants/metabolism; Aryldialkylphosphatase/antagonists & inhibitors; Aryldialkylphosphatase/blood; Enzyme Inhibitors/pharmacology; Indazoles/pharmacology; Antioxidants/chemistry; Aryldialkylphosphatase/chemistry; Aryldialkylphosphatase/metabolism; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/metabolism; Humans; Indazoles/chemistry; Indazoles/metabolism; Molecular Docking Simulation; Protein Conformation

Key words

Enzyme inhibition; indazole; molecular modeling; paraoxonase 1; purification

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aryldialkylphosphatase / Enzyme Inhibitors / Indazoles / Antioxidants Limits: Humans Language: En Journal: Arch Physiol Biochem Journal subject: BIOQUIMICA / FISIOLOGIA Year: 2019 Document type: Article Affiliation country: Turkey Country of publication: United kingdom

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