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Intracellular sorting and transcytosis of the rat transferrin receptor antibody OX26 across the blood-brain barrier in vitro is dependent on its binding affinity.
Haqqani, Arsalan S; Thom, George; Burrell, Matthew; Delaney, Christie E; Brunette, Eric; Baumann, Ewa; Sodja, Caroline; Jezierski, Anna; Webster, Carl; Stanimirovic, Danica B.
Affiliation
  • Haqqani AS; National Research Council of Canada, Human Health Therapeutics Research Centre, Ottawa, ON, Canada.
  • Thom G; Antibody Discovery and Protein Engineering, MedImmune, Milstein Building, Granta Park, Cambridge, UK.
  • Burrell M; Antibody Discovery and Protein Engineering, MedImmune, Milstein Building, Granta Park, Cambridge, UK.
  • Delaney CE; National Research Council of Canada, Human Health Therapeutics Research Centre, Ottawa, ON, Canada.
  • Brunette E; National Research Council of Canada, Human Health Therapeutics Research Centre, Ottawa, ON, Canada.
  • Baumann E; National Research Council of Canada, Human Health Therapeutics Research Centre, Ottawa, ON, Canada.
  • Sodja C; National Research Council of Canada, Human Health Therapeutics Research Centre, Ottawa, ON, Canada.
  • Jezierski A; National Research Council of Canada, Human Health Therapeutics Research Centre, Ottawa, ON, Canada.
  • Webster C; Antibody Discovery and Protein Engineering, MedImmune, Milstein Building, Granta Park, Cambridge, UK.
  • Stanimirovic DB; National Research Council of Canada, Human Health Therapeutics Research Centre, Ottawa, ON, Canada.
J Neurochem ; 146(6): 735-752, 2018 09.
Article in En | MEDLINE | ID: mdl-29877588
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Transferrin / Blood-Brain Barrier / Transcytosis / Antibodies Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neurochem Year: 2018 Document type: Article Affiliation country: Canada
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Transferrin / Blood-Brain Barrier / Transcytosis / Antibodies Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neurochem Year: 2018 Document type: Article Affiliation country: Canada